| pubmed-article:16456002 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16456002 | lifeskim:mentions | umls-concept:C0296250 | lld:lifeskim |
| pubmed-article:16456002 | lifeskim:mentions | umls-concept:C1705639 | lld:lifeskim |
| pubmed-article:16456002 | lifeskim:mentions | umls-concept:C0041485 | lld:lifeskim |
| pubmed-article:16456002 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:16456002 | lifeskim:mentions | umls-concept:C1334333 | lld:lifeskim |
| pubmed-article:16456002 | lifeskim:mentions | umls-concept:C0699032 | lld:lifeskim |
| pubmed-article:16456002 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16456002 | pubmed:dateCreated | 2006-2-3 | lld:pubmed |
| pubmed-article:16456002 | pubmed:abstractText | The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) plays a central role in T cell activation and T cell development. SLP-76 has three functional modules: an acidic domain with three key tyrosines, a central proline-rich domain, and a C-terminal Src homology 2 domain. Of these, mutation of the three N-terminal tyrosines (Y112, Y128, and Y145) results in the most profound effects on T cell development and function. Y112 and Y128 associate with Vav and Nck, two proteins shown to be important for TCR-induced phosphorylation of proximal signaling substrates, Ca(2+) flux, and actin reorganization. Y145 has been shown to be important for optimal association of SLP-76 with inducible tyrosine kinase, a key regulator of T cell function. To investigate further the role of the phosphorylatable tyrosines of SLP-76 in TCR signaling, cell lines and primary T cells expressing SLP-76 with mutations in individual or paired tyrosine residues were analyzed. These studies show that Tyr(145) of SLP-76 is the most critical tyrosine for both T cell function in vitro and T cell development in vivo. | lld:pubmed |
| pubmed-article:16456002 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16456002 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16456002 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16456002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16456002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16456002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16456002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16456002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16456002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16456002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16456002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16456002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16456002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16456002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16456002 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16456002 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16456002 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16456002 | pubmed:author | pubmed-author:SchwartzbergP... | lld:pubmed |
| pubmed-article:16456002 | pubmed:author | pubmed-author:KoretzkyGary... | lld:pubmed |
| pubmed-article:16456002 | pubmed:author | pubmed-author:FinkelsteinLi... | lld:pubmed |
| pubmed-article:16456002 | pubmed:author | pubmed-author:SingerAndrew... | lld:pubmed |
| pubmed-article:16456002 | pubmed:author | pubmed-author:JordanMartha... | lld:pubmed |
| pubmed-article:16456002 | pubmed:author | pubmed-author:SadlerJeffrey... | lld:pubmed |
| pubmed-article:16456002 | pubmed:author | pubmed-author:AustinJessica... | lld:pubmed |
| pubmed-article:16456002 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16456002 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16456002 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:16456002 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16456002 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16456002 | pubmed:pagination | 2430-8 | lld:pubmed |
| pubmed-article:16456002 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:meshHeading | pubmed-meshheading:16456002... | lld:pubmed |
| pubmed-article:16456002 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16456002 | pubmed:articleTitle | Functional hierarchy of the N-terminal tyrosines of SLP-76. | lld:pubmed |
| pubmed-article:16456002 | pubmed:affiliation | Signal Transduction Program, Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA. | lld:pubmed |
| pubmed-article:16456002 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16456002 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16456002 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16822 | entrezgene:pubmed | pubmed-article:16456002 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16456002 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16456002 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16456002 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16456002 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16456002 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16456002 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16456002 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16456002 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16456002 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16456002 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16456002 | lld:pubmed |
