GENERIC 16455306

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0008976, umls-concept:C0282443, umls-concept:C1511481, umls-concept:C1552617, umls-concept:C1707689
pubmed:issue	4
pubmed:dateCreated	2006-7-3
pubmed:abstractText	In 1979, Zelen described a trial method of randomising participants before acquiring consent in order to enhance recruitment to clinical trials. The method has been criticised ethically due to lack of consent and scientifically due to high crossover rates. This paper reviews recent published trials using this method and describes the reasons authors gave for using the method, examines the crossover rates, and looks at the quality of identified trials.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101242342
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	1551-7144
pubmed:author	pubmed-author:AdamsonJoyJ, pubmed-author:CockayneSarahS, pubmed-author:PufferSuezannS, pubmed-author:TorgersonDavid JDJ
pubmed:issnType	Print
pubmed:volume	27
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	305-19
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:16455306-Cross-Over Studies, pubmed-meshheading:16455306-Humans, pubmed-meshheading:16455306-Patient Selection, pubmed-meshheading:16455306-Randomized Controlled Trials as Topic
pubmed:year	2006
pubmed:articleTitle	Review of randomised trials using the post-randomised consent (Zelen's) design.
pubmed:affiliation	York Trials Unit, Department of Health Sciences, University of York, York YO10 5DD, UK.
pubmed:publicationType	Journal Article, Review