|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2006-2-20
|
|
pubmed:abstractText |
The family of c-Jun NH2-terminal kinases (JNK) plays important roles in embryonic development and in cellular responses to stress. Toxic metals and their compounds are potent activators of JNK in mammalian cells. The mechanism of mammalian JNK activation by cadmium and sodium arsenite involves toxicant-induced oxidative stress. The study of mammalian signaling pathways to JNK is complicated by the significant degree of redundancy among upstream JNK regulators, especially at the level of JNK kinase kinases (JNKKK).
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-10207617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-10230788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-10354710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-10464319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-10487205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-10611349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-10618720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-10797012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-10823906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-10873670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-11057897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-11242034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-11506194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-11574474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-11752672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-11790549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-12209126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-12351623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-12471242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-15139849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-15270699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-15302099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-15517128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-15598880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-15704176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-2546864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-3809741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-6487352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-7600581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-7803762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-7826642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-8472835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-8654373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-8757935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-8824197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-8910292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-8947050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-9079627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-9089888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-9154836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-9493007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-9535875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-9564042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-9661124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-9792807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451733-9820741
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1471-2121
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
7
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16451733-Animals,
pubmed-meshheading:16451733-Arsenites,
pubmed-meshheading:16451733-Cadmium,
pubmed-meshheading:16451733-Cell Line,
pubmed-meshheading:16451733-Drosophila Proteins,
pubmed-meshheading:16451733-Drosophila melanogaster,
pubmed-meshheading:16451733-Enzyme Activation,
pubmed-meshheading:16451733-Hemiptera,
pubmed-meshheading:16451733-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:16451733-Kinetics,
pubmed-meshheading:16451733-MAP Kinase Kinase Kinase 1,
pubmed-meshheading:16451733-MAP Kinase Kinase Kinase 4,
pubmed-meshheading:16451733-Mammals,
pubmed-meshheading:16451733-p38 Mitogen-Activated Protein Kinases
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells.
|
|
pubmed:affiliation |
Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, Oregon 97239, USA. ryabinio@ohsu.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
