Linked Life Data

16406211

Source:http://linkedlifedata.com/resource/pubmed/id/16406211

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-2-10
pubmed:abstractText
Molecular motors have prominent functions in organelle transport, cytoskeletal organization, division and motility. The dyneins are one of the three families of cytoskeleton-based molecular motors and they travel along the cytoplasmic microtubule network towards the minus end of the microtubule. This directed movement is used by DNA viruses to deliver their infectious genome and proteins to the host cell nucleus. In recent studies, it has been hypothesized that Agrobacterium species use a similar pathway to deliver their infectious unit--a large complex between single-stranded DNA and proteins--to the host cell nucleus and that a karyophilic protein carrier that can deliver synthetic DNA to the nucleus is also driven by a dynein motor. These studies shed light on the mechanism of Agrobacterium-mediated genetic transformation and could lead to new methods for the efficient transfection of synthetic DNA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0966-842X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-3
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
On tracks and locomotives: the long route of DNA to the nucleus.
pubmed:affiliation
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. ttzfira@umich.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't