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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-4-10
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pubmed:abstractText |
A pharmacokinetic interaction between oral DA-8159 and amlodipine was evaluated in male Sprague-Dawley rats. In rats pretreated with troleandomycin (a main inhibitor of CYP3A1/2 in rats), the AUC(0-6 h) of amlodipine was significantly greater than the controls (34.5+/-6.01 compared with 28.0+/-4.70 microg min/ml), indicating that amlodipine is metabolized via CYP3A1/2 in rats. It was reported that the metabolism of DA-8159 and the formation of DA-8164 (a metabolite of DA-8159) were mainly mediated via CYP3A1/2 in rats, and amlodipine significantly inhibited the CYP3A2 in rats. Therefore, a pharmacokinetic interaction between the two drugs could be expected. However, after oral administration of DA-8159 at a dose of 30 mg/kg with or without oral amlodipine at a dose of 5 mg/kg to rats, the pharmacokinetic parameters of DA-8159 and DA-8164 were not significantly different between the two groups of rats. Similar results were also obtained from amlodipine between with and without DA-8159. The above data indicated that the pharmacokinetic interaction between oral DA-8159 and amlodipine was almost negligible in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amlodipine,
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyp3a1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A,
http://linkedlifedata.com/resource/pubmed/chemical/DA-8164,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Troleandomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/tiropramide,
http://linkedlifedata.com/resource/pubmed/chemical/udenafil
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0142-2782
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pubmed:author |
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pubmed:copyrightInfo |
2006 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125-31
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16400709-Administration, Oral,
pubmed-meshheading:16400709-Amlodipine,
pubmed-meshheading:16400709-Animals,
pubmed-meshheading:16400709-Area Under Curve,
pubmed-meshheading:16400709-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:16400709-Chromatography, High Pressure Liquid,
pubmed-meshheading:16400709-Cytochrome P-450 CYP3A,
pubmed-meshheading:16400709-Drug Interactions,
pubmed-meshheading:16400709-Enzyme Inhibitors,
pubmed-meshheading:16400709-Feces,
pubmed-meshheading:16400709-Gastrointestinal Tract,
pubmed-meshheading:16400709-Injections, Intraperitoneal,
pubmed-meshheading:16400709-Injections, Intravenous,
pubmed-meshheading:16400709-Male,
pubmed-meshheading:16400709-Penile Erection,
pubmed-meshheading:16400709-Phosphodiesterase Inhibitors,
pubmed-meshheading:16400709-Pyrimidines,
pubmed-meshheading:16400709-Rats,
pubmed-meshheading:16400709-Rats, Sprague-Dawley,
pubmed-meshheading:16400709-Sulfonamides,
pubmed-meshheading:16400709-Time Factors,
pubmed-meshheading:16400709-Troleandomycin,
pubmed-meshheading:16400709-Tyrosine
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pubmed:year |
2006
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pubmed:articleTitle |
Negligible pharmacokinetic interaction between oral DA-8159, a new erectogenic, and amlodipine in rats.
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pubmed:affiliation |
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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