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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1992-9-1
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pubmed:abstractText |
Although ependymomas comprise 5-10% of pediatric brain tumors, consistent cytogenetic aberrations have not been identified in these neoplasms. We report karyotypes for two ependymomas. A predominantly well-differentiated ependymoma contained several numerical chromosome aberrations, including monosomy 22. In contrast, an anaplastic ependymoma had a more complex karyotype that included loss of one chromosome 22 homologue and a balanced translocation at q13.3 in the remaining 22 homologue. These findings suggest the location of an ependymoma tumor suppressor gene on the long arm of chromosome 22.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0165-4608
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1638502-Brain Neoplasms,
pubmed-meshheading:1638502-Cerebral Ventricle Neoplasms,
pubmed-meshheading:1638502-Child,
pubmed-meshheading:1638502-Child, Preschool,
pubmed-meshheading:1638502-Chromosomes, Human, Pair 22,
pubmed-meshheading:1638502-Ependymoma,
pubmed-meshheading:1638502-Genes, Tumor Suppressor,
pubmed-meshheading:1638502-Humans,
pubmed-meshheading:1638502-Male,
pubmed-meshheading:1638502-Monosomy,
pubmed-meshheading:1638502-Translocation, Genetic
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pubmed:year |
1992
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pubmed:articleTitle |
Cytogenetic evidence for a chromosome 22 tumor suppressor gene in ependymoma.
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pubmed:affiliation |
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
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