| pubmed-article:16371508 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16371508 | lifeskim:mentions | umls-concept:C0074447 | lld:lifeskim |
| pubmed-article:16371508 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16371508 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
| pubmed-article:16371508 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
| pubmed-article:16371508 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
| pubmed-article:16371508 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16371508 | pubmed:dateCreated | 2006-2-27 | lld:pubmed |
| pubmed-article:16371508 | pubmed:abstractText | Shiga toxin (Stx) is composed of an A-moiety that inhibits protein synthesis after translocation into the cytosol, and a B-moiety that binds to Gb3 at the cell surface and mediates endocytosis of the toxin. After endocytosis, Stx is transported retrogradely to the endoplasmic reticulum, and then the A-fragment enters the cytosol. In this study, we have investigated whether toxin-induced signaling is involved in its entry. Stx was found to activate Syk and induce rapid tyrosine phosphorylation of several proteins, one protein being clathrin heavy chain. Toxin-induced clathrin phosphorylation required Syk activity, and in cells overexpressing Syk, a complex containing clathrin and Syk could be demonstrated. Depletion of Syk by small interfering RNA, expression of a dominant negative Syk mutant (Syk KD), or treatment with the Syk inhibitor piceatannol inhibited not only Stx-induced clathrin phosphorylation but also endocytosis of the toxin. Also, Golgi transport of Stx was inhibited under all these conditions. In conclusion, our data suggest that Stx regulates its entry into target cells. | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16371508 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16371508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16371508 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16371508 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16371508 | pubmed:issn | 1059-1524 | lld:pubmed |
| pubmed-article:16371508 | pubmed:author | pubmed-author:SpilsbergBjør... | lld:pubmed |
| pubmed-article:16371508 | pubmed:author | pubmed-author:SandvigKirste... | lld:pubmed |
| pubmed-article:16371508 | pubmed:author | pubmed-author:LauvrakSilje... | lld:pubmed |
| pubmed-article:16371508 | pubmed:author | pubmed-author:TorgersenMari... | lld:pubmed |
| pubmed-article:16371508 | pubmed:author | pubmed-author:IversenTore-G... | lld:pubmed |
| pubmed-article:16371508 | pubmed:author | pubmed-author:WälchliSébast... | lld:pubmed |
| pubmed-article:16371508 | pubmed:author | pubmed-author:SlagsvoldHege... | lld:pubmed |
| pubmed-article:16371508 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16371508 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:16371508 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16371508 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16371508 | pubmed:pagination | 1096-109 | lld:pubmed |
| pubmed-article:16371508 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
| pubmed-article:16371508 | pubmed:meshHeading | pubmed-meshheading:16371508... | lld:pubmed |
| pubmed-article:16371508 | pubmed:meshHeading | pubmed-meshheading:16371508... | lld:pubmed |
| pubmed-article:16371508 | pubmed:meshHeading | pubmed-meshheading:16371508... | lld:pubmed |
| pubmed-article:16371508 | pubmed:meshHeading | pubmed-meshheading:16371508... | lld:pubmed |
| pubmed-article:16371508 | pubmed:meshHeading | pubmed-meshheading:16371508... | lld:pubmed |
| pubmed-article:16371508 | pubmed:meshHeading | pubmed-meshheading:16371508... | lld:pubmed |
