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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-12-6
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pubmed:abstractText |
Systemic sclerosis (scleroderma) is a multisystem fibrotic disease that commonly manifests with severe Raynaud's phenomenon and slow-healing cutaneous ulcerations. Reduced nitric oxide levels have been proposed to play a role in the pathogenesis of vascular disease in scleroderma, and therefore sildenafil (which increases nitric oxide levels) is an attractive therapeutic prospect. We describe a patient with limited cutaneous systemic sclerosis who presented with severe nonhealing finger ulcerations despite conventional management, who showed marked improvement with oral sildenafil.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0315-162X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2440-2
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16331780-Administration, Oral,
pubmed-meshheading:16331780-Adult,
pubmed-meshheading:16331780-Fingers,
pubmed-meshheading:16331780-Humans,
pubmed-meshheading:16331780-Male,
pubmed-meshheading:16331780-Piperazines,
pubmed-meshheading:16331780-Purines,
pubmed-meshheading:16331780-Scleroderma, Systemic,
pubmed-meshheading:16331780-Skin Ulcer,
pubmed-meshheading:16331780-Sulfones,
pubmed-meshheading:16331780-Treatment Outcome,
pubmed-meshheading:16331780-Vasodilator Agents
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pubmed:year |
2005
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pubmed:articleTitle |
Severe refractory fingertip ulcerations in a patient with scleroderma: successful treatment with sildenafil.
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pubmed:affiliation |
Section on Rheumatology and Immunology, Department of Internal Medicine, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina, USA. leecolglazier@hotmail.com
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pubmed:publicationType |
Journal Article,
Case Reports
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