| pubmed-article:1632795 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1632795 | lifeskim:mentions | umls-concept:C0026030 | lld:lifeskim |
| pubmed-article:1632795 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:1632795 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1632795 | lifeskim:mentions | umls-concept:C0023775 | lld:lifeskim |
| pubmed-article:1632795 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1632795 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1632795 | pubmed:dateCreated | 1992-8-14 | lld:pubmed |
| pubmed-article:1632795 | pubmed:abstractText | Microsomal NADPH-driven electron transport is known to initiate lipid peroxidation by activating oxygen in the presence of iron. This pro-oxidant effect can mask an antioxidant function of NADPH-driven electron transport in microsomes via vitamin E recycling from its phenoxyl radicals formed in the course of peroxidation. To test this hypothesis we studied the effects of NADPH on the endogenous vitamin E content and lipid peroxidation induced in liver microsomes by an oxidation system independent of iron: an azo-initiator of peroxyl radicals, 2,2'-azobis (2,4-dimethylvaleronitrile), (AMVN), in the presence of an iron chelator deferoxamine. We found that under conditions NADPH: (i) inhibited lipid peroxidation; (ii) this inhibitory effect was less pronounced in microsomes from vitamin E-deficient rats than in microsomes from normal rats; (iii) protected vitamin E from oxidative destruction; (iv) reduced chromanoxyl radicals of vitamin E homologue with a 6-carbon side-chain, chromanol-alpha-C-6. Thus NADPH-driven electron transport may function both to initiate and/or inhibit lipid peroxidation in microsomes depending on the availability of transition metal catalysts. | lld:pubmed |
| pubmed-article:1632795 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1632795 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1632795 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1632795 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1632795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1632795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1632795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1632795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1632795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1632795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1632795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1632795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1632795 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1632795 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1632795 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:1632795 | pubmed:author | pubmed-author:PackerLL | lld:pubmed |
| pubmed-article:1632795 | pubmed:author | pubmed-author:KaganV EVE | lld:pubmed |
| pubmed-article:1632795 | pubmed:author | pubmed-author:SerbinovaE... | lld:pubmed |
| pubmed-article:1632795 | pubmed:author | pubmed-author:SafadiAA | lld:pubmed |
| pubmed-article:1632795 | pubmed:author | pubmed-author:CatudiocJ DJD | lld:pubmed |
| pubmed-article:1632795 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1632795 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1632795 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:1632795 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1632795 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1632795 | pubmed:pagination | 74-80 | lld:pubmed |
| pubmed-article:1632795 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1632795 | pubmed:meshHeading | pubmed-meshheading:1632795-... | lld:pubmed |
| pubmed-article:1632795 | pubmed:meshHeading | pubmed-meshheading:1632795-... | lld:pubmed |
| pubmed-article:1632795 | pubmed:meshHeading | pubmed-meshheading:1632795-... | lld:pubmed |
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| pubmed-article:1632795 | pubmed:meshHeading | pubmed-meshheading:1632795-... | lld:pubmed |
| pubmed-article:1632795 | pubmed:meshHeading | pubmed-meshheading:1632795-... | lld:pubmed |
| pubmed-article:1632795 | pubmed:meshHeading | pubmed-meshheading:1632795-... | lld:pubmed |
| pubmed-article:1632795 | pubmed:meshHeading | pubmed-meshheading:1632795-... | lld:pubmed |
| pubmed-article:1632795 | pubmed:meshHeading | pubmed-meshheading:1632795-... | lld:pubmed |
| pubmed-article:1632795 | pubmed:meshHeading | pubmed-meshheading:1632795-... | lld:pubmed |
| pubmed-article:1632795 | pubmed:meshHeading | pubmed-meshheading:1632795-... | lld:pubmed |
| pubmed-article:1632795 | pubmed:meshHeading | pubmed-meshheading:1632795-... | lld:pubmed |
| pubmed-article:1632795 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1632795 | pubmed:articleTitle | NADPH-dependent inhibition of lipid peroxidation in rat liver microsomes. | lld:pubmed |
| pubmed-article:1632795 | pubmed:affiliation | Department of Molecular and Cell Biology, University of California, Berkeley 94720. | lld:pubmed |
| pubmed-article:1632795 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1632795 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1632795 | lld:pubmed |
