Linked Life Data

16320257

Source:http://linkedlifedata.com/resource/pubmed/id/16320257

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-12-6
pubmed:abstractText
Ghrelin is a hormone that stimulates growth hormone secretion and signals energy insufficiency via interaction with its receptor, the growth hormone secretagogue receptor (GHSR). The GHSR is located in both the central nervous system and the periphery. Its distribution in the CNS, as assessed by in situ hybridization histochemistry (ISHH), has been described previously in a few mammalian species, although these studies were limited by either the detail provided or the extent of the regions examined. In the present study, we systematically examined the distribution of GHSR mRNA in the adult rat and mouse brains and cervical spinal cords by using ISHH with novel cRNA probes specific for the mRNA encoding functional GHSR (the type 1a variant). We confirmed GHSR mRNA expression in several hypothalamic nuclei, many of which have long been recognized as playing roles in body weight and food intake. GHSR also was found in several other regions previously unknown to express GHSR mRNA, including many parasympathetic preganglionic neurons. Additionally, we found GHSR mRNA within all three components of the dorsal vagal complex, including the area postrema, the nucleus of the solitary tract, and the dorsal motor nucleus of the vagus. Finally, we examined the coexpression of GHSR with tyrosine hydroxylase and cholecystokinin and demonstrate a high degree of GHSR mRNA expression within dopaminergic, cholecystokinin-containing neurons of the substantia nigra and ventral tegmental area.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9967
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
494
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
528-48
pubmed:dateRevised
2011-5-6
pubmed:meshHeading
pubmed-meshheading:16320257-Animals, pubmed-meshheading:16320257-Autonomic Fibers, Preganglionic, pubmed-meshheading:16320257-Brain, pubmed-meshheading:16320257-Cervical Vertebrae, pubmed-meshheading:16320257-Cholecystokinin, pubmed-meshheading:16320257-Ganglia, Parasympathetic, pubmed-meshheading:16320257-Gene Expression, pubmed-meshheading:16320257-In Situ Hybridization, pubmed-meshheading:16320257-Male, pubmed-meshheading:16320257-Mice, pubmed-meshheading:16320257-Mice, Inbred C57BL, pubmed-meshheading:16320257-RNA, Messenger, pubmed-meshheading:16320257-Rats, pubmed-meshheading:16320257-Rats, Sprague-Dawley, pubmed-meshheading:16320257-Receptors, G-Protein-Coupled, pubmed-meshheading:16320257-Receptors, Ghrelin, pubmed-meshheading:16320257-Specific Pathogen-Free Organisms, pubmed-meshheading:16320257-Spinal Cord, pubmed-meshheading:16320257-Tissue Distribution, pubmed-meshheading:16320257-Tyrosine 3-Monooxygenase
pubmed:year
2006
pubmed:articleTitle
Expression of ghrelin receptor mRNA in the rat and the mouse brain.
pubmed:affiliation
Department of Medicine and Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural