Linked Life Data

16310429

Source:http://linkedlifedata.com/resource/pubmed/id/16310429

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2005-11-28
pubmed:abstractText
We examined the hypothesis that myocardial contrast echocardiography (MCE) is superior to conventional electrocardiographic, echocardiographic, and troponin I criteria for the diagnosis of acute coronary syndrome. We prospectively enrolled 114 consecutive patients (60+/-10 years of age, 73 men) who presented to the emergency room with chest pain on exertion and at rest. Exclusion criteria included an age<40 years, presence of Q wave or ST-segment elevation, and a poor echocardiographic window. Echocardiography and MCE were performed to assess regional wall motion abnormalities (RWMAs) and myocardial perfusion defects by using continuous infusion of perfluorocarbon-exposed sonicated dextrose albumin. Acute coronary syndrome was confirmed in 87 patients. There were no deaths; 46 patients had acute myocardial infarction, and 41 patients required urgent revascularization. On multiple logistic regression analysis, myocardial perfusion defect (odd ratio 87, p<0.001) was the only independent variable for diagnosing acute coronary syndrome. Myocardial perfusion defect (odd ratio 21, p=0.001) and troponin I levels (odd ratio 3, p=0.009) were independent predictors for acute myocardial infarction. The sensitivity of myocardial perfusion defect for diagnosing acute coronary syndrome was 77%, which is significantly higher than the sensitivities of ST change, troponin I increase, and RWMA (28%, 34%, and 49%, respectively), with similar specificities of 85% to 96%. In conclusion, MCE is more sensitive than the currently used electrocardiographic and troponin I criteria, and evaluation of myocardial perfusion defect by MCE complements RWMA analysis by conventional echocardiography for accurate diagnosis of acute coronary syndrome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9149
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1498-502
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16310429-Acute Disease, pubmed-meshheading:16310429-Coronary Disease, pubmed-meshheading:16310429-Diagnosis, Differential, pubmed-meshheading:16310429-Echocardiography, Doppler, pubmed-meshheading:16310429-Electrocardiography, pubmed-meshheading:16310429-Female, pubmed-meshheading:16310429-Fluorocarbons, pubmed-meshheading:16310429-Follow-Up Studies, pubmed-meshheading:16310429-Glucose, pubmed-meshheading:16310429-Humans, pubmed-meshheading:16310429-Infusions, Intravenous, pubmed-meshheading:16310429-Male, pubmed-meshheading:16310429-Middle Aged, pubmed-meshheading:16310429-Myocardial Contraction, pubmed-meshheading:16310429-Odds Ratio, pubmed-meshheading:16310429-Prospective Studies, pubmed-meshheading:16310429-Reproducibility of Results, pubmed-meshheading:16310429-Risk Assessment, pubmed-meshheading:16310429-Sensitivity and Specificity, pubmed-meshheading:16310429-Serum Albumin, pubmed-meshheading:16310429-Severity of Illness Index, pubmed-meshheading:16310429-Syndrome, pubmed-meshheading:16310429-Troponin I
pubmed:year
2005
pubmed:articleTitle
Efficacy of myocardial contrast echocardiography in the diagnosis and risk stratification of acute coronary syndrome.
pubmed:affiliation
The Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea. dhkang@amc.seoul.kr
pubmed:publicationType
Journal Article, Comparative Study