Source:http://linkedlifedata.com/resource/pubmed/id/16247433
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2005-12-1
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| pubmed:abstractText |
The current study attempted to evaluate the association between the IL-10 promoter gene single nucleotide polymorphism (SNP) and invasive pulmonary aspergillosis (IPA) after allogeneic stem cell transplantation (SCT) in 105 patients. Three single-nucleotide polymorphisms were investigated in the proximal region of the IL-10 promoter gene (-1082/-819/-592). Two haplotypes (1082*A/819*T/592*A [ATA] and 1082*A/819*C/592*C [ACC]) were found in the current study. The overall incidence of IPA was estimated as 14.1+/-4.5% with a median onset at 186 days post-transplant (62 approximately 405 days). An increased occurrence of IPA was noted dependent on the IL-10 haplotype (0% vs 11.5+/-6.4% vs 19.7+/-7.7% for ACC/ACC vs ATA/ACC vs ATA/ATA haplotype, P=0.0307 when comparing ACC with non-ACC haplotype). In a multivariate survival analysis using Cox's proportional hazard model, the IL-10 promoter gene SNPs were identified as an independent predictive factor for the development of IPA (P=0.012, hazard ratio (HR) 9.3), along with an histocompatibility leukocyte antigen (HLA)-identical donor (P=0.005, HR 16.3), the CD34+ cell dose transplanted (P=0.004, HR 26.5), and time-dependent chronic graft-versus-host disease (GVHD; P=0.049, HR 16.0). The IL-10 ACC haplotype was found to have an apparent protective role in the development of IPA after allogeneic transplantation, regardless of HLA-disparity or chronic GVHD.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0268-3369
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1089-95
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:16247433-Adolescent,
pubmed-meshheading:16247433-Adult,
pubmed-meshheading:16247433-Antigens, CD34,
pubmed-meshheading:16247433-Aspergillosis,
pubmed-meshheading:16247433-Female,
pubmed-meshheading:16247433-Graft vs Host Disease,
pubmed-meshheading:16247433-HLA Antigens,
pubmed-meshheading:16247433-Haplotypes,
pubmed-meshheading:16247433-Humans,
pubmed-meshheading:16247433-Interleukin-10,
pubmed-meshheading:16247433-Lung,
pubmed-meshheading:16247433-Male,
pubmed-meshheading:16247433-Middle Aged,
pubmed-meshheading:16247433-Multivariate Analysis,
pubmed-meshheading:16247433-Polymorphism, Genetic,
pubmed-meshheading:16247433-Polymorphism, Single Nucleotide,
pubmed-meshheading:16247433-Promoter Regions, Genetic,
pubmed-meshheading:16247433-Proportional Hazards Models,
pubmed-meshheading:16247433-Stem Cell Transplantation,
pubmed-meshheading:16247433-Time Factors,
pubmed-meshheading:16247433-Transplantation, Homologous,
pubmed-meshheading:16247433-Treatment Outcome
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Protective role of interleukin-10 promoter gene polymorphism in the pathogenesis of invasive pulmonary aspergillosis after allogeneic stem cell transplantation.
|
| pubmed:affiliation |
Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|