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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1992-8-11
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pubmed:abstractText |
Valproic acid has previously been demonstrated to decrease the secretion of multiple pituitary hormones; however, clinical symptoms associated with decreased hormone secretion have not been described. A girl is reported with complex partial seizures who was treated with valproic acid from age 10 years, 7 months to 12 years, 1 month and during this time had an arrest of both growth and secondary sexual development. Two months after discontinuing valproic acid she had resumption of both pubertal growth and maturation. A prospective controlled study is needed to determine more precisely the effects of valproic acid on growth and development.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0887-8994
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
8
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
229-31
|
pubmed:dateRevised |
2006-5-23
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pubmed:meshHeading |
pubmed-meshheading:1622523-Body Height,
pubmed-meshheading:1622523-Body Weight,
pubmed-meshheading:1622523-Child,
pubmed-meshheading:1622523-Epilepsy, Complex Partial,
pubmed-meshheading:1622523-Evoked Potentials,
pubmed-meshheading:1622523-Female,
pubmed-meshheading:1622523-Humans,
pubmed-meshheading:1622523-Psychosexual Development,
pubmed-meshheading:1622523-Puberty,
pubmed-meshheading:1622523-Valproic Acid
|
pubmed:articleTitle |
Pubertal arrest associated with valproic acid therapy.
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pubmed:affiliation |
Department of Pediatrics, Wright State University, Dayton, Ohio 45402.
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pubmed:publicationType |
Journal Article,
Case Reports
|