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pubmed-article:16204011pubmed:abstractTextMost cases of non-small-cell lung cancer (NSCLC) with dramatic responses to gefitinib have specific activating mutations in the epidermal growth factor receptor (EGFR), but the predictive value of these mutations has not been defined in large clinical trials. The goal of this study was to determine the contribution of molecular alterations in EGFR to response and survival within the phase II (IDEAL) and phase III (INTACT) trials of gefitinib.lld:pubmed
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pubmed-article:16204011pubmed:articleTitleEpidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials.lld:pubmed
pubmed-article:16204011pubmed:affiliationMassachusetts General Hospital Cancer Center and Department of Pathology, Harvard Medical School, Charlestown, MA 02129, USA.lld:pubmed
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pubmed-article:16204011pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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pubmed-article:16204011pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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