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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-10-5
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pubmed:abstractText |
A substituted 3H-indole quaternary ammonium molecule was designed and synthesized using hexamethylphosphoramide (HMPA) as a solvent. The products were purified and characterized by IR, 1H-NMR, MS and elemental analysis. The binding reaction of this compound with bovine serum albumin (BSA) in aqueous solution was studied using fluorescence. Their binding constant is Ka = 1.995 x 10(5) dm3 x mol(-1) and the binding site number is n = 1.12. It is confirmed that the combination is a single static quenching process.
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pubmed:language |
chi
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1000-0593
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
857-60
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pubmed:meshHeading |
pubmed-meshheading:16201357-Algorithms,
pubmed-meshheading:16201357-Animals,
pubmed-meshheading:16201357-Binding Sites,
pubmed-meshheading:16201357-Cattle,
pubmed-meshheading:16201357-Fluorescence,
pubmed-meshheading:16201357-Hempa,
pubmed-meshheading:16201357-Indoles,
pubmed-meshheading:16201357-Kinetics,
pubmed-meshheading:16201357-Models, Chemical,
pubmed-meshheading:16201357-Molecular Structure,
pubmed-meshheading:16201357-Protein Binding,
pubmed-meshheading:16201357-Quaternary Ammonium Compounds,
pubmed-meshheading:16201357-Serum Albumin, Bovine,
pubmed-meshheading:16201357-Spectrometry, Fluorescence,
pubmed-meshheading:16201357-Water
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pubmed:year |
2005
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pubmed:articleTitle |
[Synthesis of substituted 3H-indole quaternary ammonium salt and study on its interaction with bovine serum albumin by fluorescence].
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pubmed:affiliation |
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
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pubmed:publicationType |
Journal Article,
English Abstract
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