| pubmed-article:1620122 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1620122 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:1620122 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:1620122 | lifeskim:mentions | umls-concept:C1564674 | lld:lifeskim |
| pubmed-article:1620122 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1620122 | lifeskim:mentions | umls-concept:C1518803 | lld:lifeskim |
| pubmed-article:1620122 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:1620122 | pubmed:dateCreated | 1992-8-6 | lld:pubmed |
| pubmed-article:1620122 | pubmed:abstractText | Oct-2 is a transcription factor that binds specifically to octamer DNA motifs in the promoters of immunoglobulin and interleukin-2 genes. All tumor cell lines from the B-cell lineage and a few from the T-cell lineage express Oct-2. To address the role of Oct-2 in the T-cell lineage, we studied the expression of Oct-2 mRNA and protein in nontransformed human and mouse T cells. Oct-2 was found in CD4+ and CD8+ T cells prepared from human peripheral blood and in mouse lymph node T cells. In a T-cell clone specific for pigeon cytochrome c in the context of I-Ek, Oct-2 was induced by antigen stimulation, with the increase in Oct-2 protein seen first at 3 h after activation and continuing for at least 24 h. Oct-2 mRNA induction during antigen-driven T-cell activation was blocked by cyclosporin A, as well as by protein synthesis inhibitors. These results suggest that Oct-2 participates in transcriptional regulation during T-cell activation. The relatively delayed kinetics of Oct-2 induction suggests that Oct-2 mediates the changes in gene expression which occur many hours or days following antigen stimulation of T lymphocytes. | lld:pubmed |
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| pubmed-article:1620122 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1620122 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1620122 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1620122 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1620122 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:1620122 | pubmed:author | pubmed-author:MAH CHC | lld:pubmed |
| pubmed-article:1620122 | pubmed:author | pubmed-author:DolzAA | lld:pubmed |
| pubmed-article:1620122 | pubmed:author | pubmed-author:KangS MSM | lld:pubmed |
| pubmed-article:1620122 | pubmed:author | pubmed-author:LenardoM JMJ | lld:pubmed |
| pubmed-article:1620122 | pubmed:author | pubmed-author:TranA CAC | lld:pubmed |
| pubmed-article:1620122 | pubmed:author | pubmed-author:TsangWW | lld:pubmed |
| pubmed-article:1620122 | pubmed:author | pubmed-author:StaudtL MLM | lld:pubmed |
| pubmed-article:1620122 | pubmed:author | pubmed-author:ScherlePP | lld:pubmed |
| pubmed-article:1620122 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1620122 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:1620122 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1620122 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1620122 | pubmed:pagination | 3149-54 | lld:pubmed |
| pubmed-article:1620122 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1620122 | pubmed:meshHeading | pubmed-meshheading:1620122-... | lld:pubmed |
| pubmed-article:1620122 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1620122 | pubmed:articleTitle | Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen. | lld:pubmed |
| pubmed-article:1620122 | pubmed:affiliation | Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:1620122 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1620122 | pubmed:publicationType | Comparative Study | lld:pubmed |
| entrez-gene:18987 | entrezgene:pubmed | pubmed-article:1620122 | lld:entrezgene |
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