Source:http://linkedlifedata.com/resource/pubmed/id/16173023
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2005-9-26
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| pubmed:abstractText |
The extent of human papillomavirus (HPV) genital shedding and type-specific diversity were evaluated in 354 consecutive women of childbearing age living in Libreville, Gabon. Detection of HPV DNA was performed by PCR using the MY09/MY11 primer set on DNA extracted from endocervical swabs. All PCR positive specimens were subjected to direct sequencing and HPV genotypes were identified on the basis of >95% sequence homology in the L1 region. Reverse line blot hybridization assay was used when a genotype could not be resolved by sequencing alone. HPV DNA was detected in 163 (46%) women, all clinically asymptomatic for HPV-related lesions. The highest prevalence of genital HPV detection (45%) was in the age group from 22 to 29 years. A total of 90 women (55%) harbored high-risk (HR) genotypes, with the most common being HPV-53 (19; 12%), HPV-58 (17; 11%), and HPV-16 (16; 10%). Low-risk genotypes were found in 36 (22%) women with HPV-54 and HPV-70 being the most frequently detected (17; 11% and 10; 6%, respectively). Finally 37 women (23%) tested positive for genotypes of unknown oncogenic risk, the most common in this category being HPV-83 (20; 12%). Multiple infections were detected in 35 (21%) women. By multivariate analysis, HPV genital shedding was significantly associated with young age (OR: 0.34; P < 0.007). The multivalent vaccine currently available against cervical carcinomas, is only active against HPV-16 and HPV-18, and will thus have a low impact in this setting.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0146-6615
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
77
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
430-8
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16173023-Adolescent,
pubmed-meshheading:16173023-Adult,
pubmed-meshheading:16173023-Amino Acid Sequence,
pubmed-meshheading:16173023-Cervix Uteri,
pubmed-meshheading:16173023-DNA, Viral,
pubmed-meshheading:16173023-Female,
pubmed-meshheading:16173023-Gabon,
pubmed-meshheading:16173023-Genotype,
pubmed-meshheading:16173023-Humans,
pubmed-meshheading:16173023-Molecular Sequence Data,
pubmed-meshheading:16173023-Papillomaviridae,
pubmed-meshheading:16173023-Papillomavirus Infections,
pubmed-meshheading:16173023-Polymerase Chain Reaction,
pubmed-meshheading:16173023-Polymorphism, Genetic,
pubmed-meshheading:16173023-Prevalence,
pubmed-meshheading:16173023-Risk Factors,
pubmed-meshheading:16173023-Uterine Cervical Neoplasms,
pubmed-meshheading:16173023-Vagina,
pubmed-meshheading:16173023-Viral Vaccines,
pubmed-meshheading:16173023-Virus Shedding
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| pubmed:year |
2005
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| pubmed:articleTitle |
High prevalence of high-risk oncogenic human papillomaviruses harboring atypical distribution in women of childbearing age living in Libreville, Gabon.
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| pubmed:affiliation |
Laboratoire de Virologie, Hôpital Européen Georges Pompidou, Paris, France. ali.simohamed@egp.ap-hop-paris.fr
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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