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rdf:type |
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lifeskim:mentions |
umls-concept:C0033640,
umls-concept:C0035820,
umls-concept:C0040649,
umls-concept:C0040661,
umls-concept:C0205263,
umls-concept:C0376466,
umls-concept:C0387583,
umls-concept:C1710082,
umls-concept:C1879547,
umls-concept:C2611812,
umls-concept:C2611831
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pubmed:issue |
13
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pubmed:dateCreated |
2005-9-27
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pubmed:abstractText |
Although Janus kinase (JAK)-mediated Tyr phosphorylation of signal transducers and activators of transcription (STAT) 1 and 3 is essential for the upregulation of cyclooxygenase-2 (COX-2) and the cardioprotection of late preconditioning (PC), the role of Ser phosphorylation of STAT1 and STAT3 in late PC and the upstream signaling mechanisms responsible for mediating Ser phosphorylation of STAT1 and STAT3 remain unknown.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Benzophenanthridines,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Phenanthridines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-epsilon,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-raf,
http://linkedlifedata.com/resource/pubmed/chemical/STAT Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/chelerythrine
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1971-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16172266-Alkaloids,
pubmed-meshheading:16172266-Animals,
pubmed-meshheading:16172266-Benzophenanthridines,
pubmed-meshheading:16172266-Cyclooxygenase 2,
pubmed-meshheading:16172266-DNA,
pubmed-meshheading:16172266-Enzyme Inhibitors,
pubmed-meshheading:16172266-Gene Deletion,
pubmed-meshheading:16172266-Ischemic Preconditioning, Myocardial,
pubmed-meshheading:16172266-MAP Kinase Signaling System,
pubmed-meshheading:16172266-Mice,
pubmed-meshheading:16172266-Mice, Knockout,
pubmed-meshheading:16172266-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:16172266-Myocardium,
pubmed-meshheading:16172266-Phenanthridines,
pubmed-meshheading:16172266-Phosphorylation,
pubmed-meshheading:16172266-Protein Kinase C-epsilon,
pubmed-meshheading:16172266-Proto-Oncogene Proteins c-raf,
pubmed-meshheading:16172266-STAT Transcription Factors,
pubmed-meshheading:16172266-Serine,
pubmed-meshheading:16172266-Up-Regulation
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pubmed:year |
2005
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pubmed:articleTitle |
Role of the protein kinase C-epsilon-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning.
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pubmed:affiliation |
Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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