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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
18
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|
pubmed:dateCreated |
2005-9-19
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|
pubmed:abstractText |
Malignant melanoma is a highly aggressive neoplastic disease whose incidence is increasing rapidly. In recent years, the use of interferon alpha (IFNalpha) has become the most established adjuvant immunotherapy for melanoma of advanced stage. IFNalpha is a potent inhibitor of melanoma cell proliferation, and the signal transducer and activator of transcription STAT1 is crucial for its antiproliferative action. Although advanced melanomas clinically resistant to IFNalpha are frequently characterized by inefficient STAT1 signaling, the mechanisms underlying advanced-stage interferon resistance are poorly understood.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-9822
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1629-39
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16169484-Antineoplastic Agents,
pubmed-meshheading:16169484-Blotting, Western,
pubmed-meshheading:16169484-Cell Line, Tumor,
pubmed-meshheading:16169484-Cytokines,
pubmed-meshheading:16169484-DNA Primers,
pubmed-meshheading:16169484-Drug Resistance, Neoplasm,
pubmed-meshheading:16169484-Fluorescent Antibody Technique,
pubmed-meshheading:16169484-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16169484-Humans,
pubmed-meshheading:16169484-Immunohistochemistry,
pubmed-meshheading:16169484-Immunoprecipitation,
pubmed-meshheading:16169484-Immunotherapy,
pubmed-meshheading:16169484-Interferon-alpha,
pubmed-meshheading:16169484-Melanoma,
pubmed-meshheading:16169484-RNA Interference,
pubmed-meshheading:16169484-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16169484-STAT1 Transcription Factor,
pubmed-meshheading:16169484-STAT5 Transcription Factor,
pubmed-meshheading:16169484-Signal Transduction
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pubmed:year |
2005
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pubmed:articleTitle |
STAT5 contributes to interferon resistance of melanoma cells.
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|
pubmed:affiliation |
Department of Physiological Chemistry I, Biocenter, Theodor-Boveri Institute, University of Würzburg, Am Hubland, 97074 Würzburg, Germany. claudia.wellbrock@icr.ac.uk
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
