Linked Life Data

16166186

Source:http://linkedlifedata.com/resource/pubmed/id/16166186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-9-16
pubmed:abstractText
Following the current hypothesis that acute schizophrenic psychotic illness is associated with a striatal 'hyperdopaminergic state', presynaptic integrity and dopamine transporter (DAT) density in first-episode, neuroleptic-naive schizophrenic patients was measured by single-photon-emission-tomography (SPECT) and compared with that in healthy control subjects. A new SPECT-ligand for assessment of the striatal DAT, the Technetium-99m-labelled tropane TRODAT-1 ([99mTc]TRODAT-1), was used. Ten inpatients suffering from a first acute schizophrenic episode and 10 age- and sex-matched healthy control subjects underwent SPECT with [99mTc]TRODAT-1. On the day of SPECT, psychopathological ratings were performed with the Brief Psychiatric Rating Scale (BPRS), the Positive and Negative Syndrome Scale (PANSS) and Schedule for Assessment of Negative Symptoms (SANS). Patients had not previously received any neuroleptic or antidepressant medication. Mean specific TRODAT-1 binding in the striatum did not differ significantly between the patient and the age- and sex-matched control group (1.25 vs. 1.28). Variance was significantly higher in the patient group. The data obtained with the new ligand in first-episode, drug-naive schizophrenic patients are in line with the PET results from the group of Laakso et al. in a comparable patient sample. [99mTc]TRODAT-1 seems to be a valuable new SPECT-ligand in the evaluation of the presynaptic site of the striatal dopaminergic synapse in schizophrenia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0269-8811
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
488-93
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16166186-Acute Disease, pubmed-meshheading:16166186-Adult, pubmed-meshheading:16166186-Analysis of Variance, pubmed-meshheading:16166186-Binding, Competitive, pubmed-meshheading:16166186-Brief Psychiatric Rating Scale, pubmed-meshheading:16166186-Corpus Striatum, pubmed-meshheading:16166186-Dopamine Plasma Membrane Transport Proteins, pubmed-meshheading:16166186-Female, pubmed-meshheading:16166186-Humans, pubmed-meshheading:16166186-Inpatients, pubmed-meshheading:16166186-Male, pubmed-meshheading:16166186-Organotechnetium Compounds, pubmed-meshheading:16166186-Protein Binding, pubmed-meshheading:16166186-Radioligand Assay, pubmed-meshheading:16166186-Schizophrenia, Paranoid, pubmed-meshheading:16166186-Tomography, Emission-Computed, Single-Photon, pubmed-meshheading:16166186-Tropanes
pubmed:year
2005
pubmed:articleTitle
The striatal dopamine transporter in first-episode, drug-naive schizophrenic patients: evaluation by the new SPECT-ligand[99mTc]TRODAT-1.
pubmed:affiliation
Department of Psychiatry, Ludwig-Maximilians-University Munich, Munich, Germany.
pubmed:publicationType
Journal Article, Comparative Study