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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-9-15
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pubmed:abstractText |
Herpes simplex virus type 2 (HSV-2) genes expressed in neuronal cells in response to stress stimuli that trigger latency reactivation are largely unknown. Using a chloramphenicol acetyltransferase (CAT) reporter assay we found that stress caused a significant (P < .001) increase in ICP10 expression in neuronal cells. Up-regulation correlated with activator protein (AP)-1 activation, notably c-Jun and c-Fos that bind cognate elements in the ICP10 promoter. It was blocked by mutation of the AP-1 motifs in the ICP10 promoter. ICP10 expression protected neuronal cells from stress-induced apoptosis. The data suggest that ICP10 may contribute to HSV-2 reactivation by increasing neuronal survival.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1355-0284
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
329-36
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16162476-Amino Acid Sequence,
pubmed-meshheading:16162476-Animals,
pubmed-meshheading:16162476-Cell Survival,
pubmed-meshheading:16162476-Gene Expression Regulation, Viral,
pubmed-meshheading:16162476-Genes, Reporter,
pubmed-meshheading:16162476-Heat-Shock Response,
pubmed-meshheading:16162476-Herpes Genitalis,
pubmed-meshheading:16162476-Herpesvirus 2, Human,
pubmed-meshheading:16162476-Molecular Sequence Data,
pubmed-meshheading:16162476-Neurons,
pubmed-meshheading:16162476-PC12 Cells,
pubmed-meshheading:16162476-Promoter Regions, Genetic,
pubmed-meshheading:16162476-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16162476-Rats,
pubmed-meshheading:16162476-Ribonucleotide Reductases,
pubmed-meshheading:16162476-Transcription Factor AP-1,
pubmed-meshheading:16162476-Up-Regulation
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pubmed:year |
2005
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pubmed:articleTitle |
Stress up-regulates neuronal expression of the herpes simplex virus type 2 large subunit of ribonucleotide reductase (R1; ICP10) by activating activator protein 1.
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pubmed:affiliation |
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201-1559, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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