| pubmed-article:16155181 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16155181 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:16155181 | lifeskim:mentions | umls-concept:C0039808 | lld:lifeskim |
| pubmed-article:16155181 | lifeskim:mentions | umls-concept:C1709915 | lld:lifeskim |
| pubmed-article:16155181 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:16155181 | lifeskim:mentions | umls-concept:C1311713 | lld:lifeskim |
| pubmed-article:16155181 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:16155181 | pubmed:dateCreated | 2005-9-12 | lld:pubmed |
| pubmed-article:16155181 | pubmed:abstractText | The influence of locked nucleic acid (LNA) residues on the thermodynamic properties of 2'-O-methyl RNA/RNA heteroduplexes is reported. Optical melting studies indicate that LNA incorporated into an otherwise 2'-O-methyl RNA oligonucleotide usually, but not always, enhances the stabilities of complementary duplexes formed with RNA. Several trends are apparent, including: (i) a 3' terminal U LNA and 5' terminal LNAs are less stabilizing than interior and other 3' terminal LNAs; (ii) most of the stability enhancement is achieved when LNA nucleotides are separated by at least one 2'-O-methyl nucleotide; and (iii) the effects of LNA substitutions are approximately additive when the LNA nucleotides are separated by at least one 2'-O-methyl nucleotide. An equation is proposed to approximate the stabilities of complementary duplexes formed with RNA when at least one 2'-O-methyl nucleotide separates LNA nucleotides. The sequence dependence of 2'-O-methyl RNA/RNA duplexes appears to be similar to that of RNA/RNA duplexes, and preliminary nearest-neighbor free energy increments at 37 degrees C are presented for 2'-O-methyl RNA/RNA duplexes. Internal mismatches with LNA nucleotides significantly destabilize duplexes with RNA. | lld:pubmed |
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| pubmed-article:16155181 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16155181 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16155181 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16155181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16155181 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16155181 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:16155181 | pubmed:author | pubmed-author:MathewsDavid... | lld:pubmed |
| pubmed-article:16155181 | pubmed:author | pubmed-author:TurnerDouglas... | lld:pubmed |
| pubmed-article:16155181 | pubmed:author | pubmed-author:KierzekElzbie... | lld:pubmed |
| pubmed-article:16155181 | pubmed:author | pubmed-author:KierzekRyszar... | lld:pubmed |
| pubmed-article:16155181 | pubmed:author | pubmed-author:CiesielskaAnn... | lld:pubmed |
| pubmed-article:16155181 | pubmed:author | pubmed-author:PasternakKaro... | lld:pubmed |
| pubmed-article:16155181 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16155181 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:16155181 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16155181 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16155181 | pubmed:pagination | 5082-93 | lld:pubmed |
