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pubmed-article:16130123pubmed:abstractTextGlioblastoma multiforme (GM) is the most lethal form of brain tumor, with a median survival of approximately 1 year. Treatment options are limited. Radiation therapy is a common form of treatment, but many tumors are resistant. In earlier studies, we found that gain of chromosome 7 is associated with radiation resistance in human primary GM. In this study, we extend that result to a model system in which we transferred chromosome 7 to recipient cells and confirmed radiation resistance as a function of chromosome 7 gain. We identified three candidate regions on chromosome 7 that conferred radiation resistance in our model system.lld:pubmed
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pubmed-article:16130123pubmed:authorpubmed-author:LambornKathle...lld:pubmed
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pubmed-article:16130123pubmed:copyrightInfoCopyright 2005 Wiley-Liss, Inclld:pubmed
pubmed-article:16130123pubmed:issnTypePrintlld:pubmed
pubmed-article:16130123pubmed:volume45lld:pubmed
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pubmed-article:16130123pubmed:pagination20-30lld:pubmed
pubmed-article:16130123pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:16130123pubmed:year2006lld:pubmed
pubmed-article:16130123pubmed:articleTitleChromosome transfer experiments link regions on chromosome 7 to radiation resistance in human glioblastoma multiforme.lld:pubmed
pubmed-article:16130123pubmed:affiliationBrain Tumor Research Center, Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94143-0808, USA. amisra@cc.ucsf.edulld:pubmed
pubmed-article:16130123pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16130123pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:16130123pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed