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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-7-28
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pubmed:abstractText |
The effect of arginine (Arg) was studied on norepinephrine- (1 microM) precontracted small mesenteric arteries removed from rats treated with E. coli lipopolysaccharide (LPS). The addition of L- (but not D-) Arg (1 mM) relaxed, within 3 min, the small mesenteric arteries from LPS-treated but not from control rats, the maximal relaxation (65.3 +/- 11%) being reached with less than 100 microM L-Arg. NG-Nitro-L-arginine methyl ester (1 mM) and methylene blue (10 microM) restored contractions to the level reached before addition of L-Arg. These results show that LPS induces the production of an L-Arg-derived, nitric oxide-like, relaxing factor in small mesenteric arteries.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-2999
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
211
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1612111-Animals,
pubmed-meshheading:1612111-Arginine,
pubmed-meshheading:1612111-Endotoxins,
pubmed-meshheading:1612111-Escherichia coli,
pubmed-meshheading:1612111-Lipopolysaccharides,
pubmed-meshheading:1612111-Male,
pubmed-meshheading:1612111-Mesenteric Arteries,
pubmed-meshheading:1612111-Methylene Blue,
pubmed-meshheading:1612111-Muscle, Smooth, Vascular,
pubmed-meshheading:1612111-Muscle Relaxation,
pubmed-meshheading:1612111-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:1612111-Rats,
pubmed-meshheading:1612111-Rats, Inbred Strains,
pubmed-meshheading:1612111-Vascular Resistance
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pubmed:year |
1992
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pubmed:articleTitle |
L-arginine induces relaxation of small mesenteric arteries from endotoxin-treated rats.
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pubmed:affiliation |
Laboratoire de Pharmacologie Cellulaire et Moléculaire, Université Louis Pasteur de Strasbourg, CNRS URA 0600, Illkirch, France.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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