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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007608,
umls-concept:C0021701,
umls-concept:C0024623,
umls-concept:C0086982,
umls-concept:C0205263,
umls-concept:C0334227,
umls-concept:C0387583,
umls-concept:C0521447,
umls-concept:C1269955,
umls-concept:C1413896,
umls-concept:C1879547,
umls-concept:C2699153
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|
pubmed:issue |
16
|
|
pubmed:dateCreated |
2005-8-23
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|
pubmed:abstractText |
Cysteine-rich 61 (Cyr61/CCN1) is involved in many different types of tumor development and progression. Nonetheless, the role of Cyr61 in human gastric cancer has not yet been fully characterized.Experimental design: We addressed the issue by immunohistochemical staining of 81 gastric adenocarcinoma specimens. Liposome-mediated transfection was used to introduce a Cyr61 expression vector into gastric cancer AGS cell lines. Transfectants were tested in invasion assay by a Boyden chamber. Furthermore, a cyclooxygenase-2 (COX-2) reporter assay and gel mobility shift assay were done to investigate the potential signal pathway of Cyr61.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:ChangCheng-ChiCC,
pubmed-author:ChangKing-JenKJ,
pubmed-author:ChenChih-PingCP,
pubmed-author:ChenSzu-TaST,
pubmed-author:ChenWei-JaoWJ,
pubmed-author:JengYung-MingYM,
pubmed-author:KuoMin-LiangML,
pubmed-author:LeePo-HuangPH,
pubmed-author:LinBeen-RenBR,
pubmed-author:LinMing-TsaiMT,
pubmed-author:WangMing-YangMY,
pubmed-author:ZuonChung-YaouCY
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|
pubmed:issnType |
Print
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pubmed:day |
15
|
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pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
5809-20
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|
pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16115920-Adenocarcinoma,
pubmed-meshheading:16115920-Adult,
pubmed-meshheading:16115920-Aged,
pubmed-meshheading:16115920-Aged, 80 and over,
pubmed-meshheading:16115920-Cell Line, Tumor,
pubmed-meshheading:16115920-Cell Movement,
pubmed-meshheading:16115920-Cysteine-Rich Protein 61,
pubmed-meshheading:16115920-Female,
pubmed-meshheading:16115920-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16115920-Humans,
pubmed-meshheading:16115920-Immediate-Early Proteins,
pubmed-meshheading:16115920-Immunohistochemistry,
pubmed-meshheading:16115920-Integrins,
pubmed-meshheading:16115920-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:16115920-Male,
pubmed-meshheading:16115920-Middle Aged,
pubmed-meshheading:16115920-NF-kappa B,
pubmed-meshheading:16115920-Neoplasm Invasiveness,
pubmed-meshheading:16115920-Plasmids,
pubmed-meshheading:16115920-Signal Transduction,
pubmed-meshheading:16115920-Stomach Neoplasms,
pubmed-meshheading:16115920-Transfection
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pubmed:year |
2005
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pubmed:articleTitle |
Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathway.
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pubmed:affiliation |
Department of Primary Care Medicine, National Taiwan University Hospital, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
