Linked Life Data

16102031

Source:http://linkedlifedata.com/resource/pubmed/id/16102031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2005-8-16
pubmed:abstractText
Treatment failures occur with any drug and aspirin is no exception. Evidence is growing to indicate that there are subpopulations that do not respond to antithrombotic action of aspirin. The term 'aspirin resistance' has been used to describe a number of different phenomena, including inability of aspirin to: (i) protect against cardiovascular events despite its regular intake; (ii) to affect various laboratory tests, reflecting platelet activity. Research on aspirin resistance yielded interesting results in clinical pharmacology and pharmacogenetics. Future studies will show whether genotyping for polymorphisms might be of value in everyday clinical use of aspirin. Present data indicate that in survivors of recent myocardial infarction or unstable angina, patients receiving coronary artery bypass grafts, as well as in subjects with hypercholesterolemia, aspirin resistance has to be considered when implementing antithrombotic therapy. However, in individual patients the available laboratory tests are of no particular use to predict reliably the clinical outcome or to guide in making therapeutic decision. Prospective clinical trials seem necessary to reach such conclusions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1538-7933
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1655-62
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:16102031-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:16102031-Aspirin, pubmed-meshheading:16102031-Cardiovascular Diseases, pubmed-meshheading:16102031-Clinical Trials as Topic, pubmed-meshheading:16102031-Drug Resistance, pubmed-meshheading:16102031-Genetic Variation, pubmed-meshheading:16102031-Genotype, pubmed-meshheading:16102031-Humans, pubmed-meshheading:16102031-Hypercholesterolemia, pubmed-meshheading:16102031-Models, Biological, pubmed-meshheading:16102031-Models, Genetic, pubmed-meshheading:16102031-Myocardial Infarction, pubmed-meshheading:16102031-Platelet Membrane Glycoproteins, pubmed-meshheading:16102031-Polymorphism, Genetic, pubmed-meshheading:16102031-Prostaglandin-Endoperoxide Synthases, pubmed-meshheading:16102031-Time Factors, pubmed-meshheading:16102031-Treatment Outcome
pubmed:year
2005
pubmed:articleTitle
Aspirin resistance.
pubmed:affiliation
Department of Medicine, Jagiellonian University School of Medicine, Cracow, Poland. mmszczek@cyf-kr.edu.pl
pubmed:publicationType
Journal Article, Review