Linked Life Data

1606756

Source:http://linkedlifedata.com/resource/pubmed/id/1606756

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-7-21
pubmed:abstractText
The effect of eosinophil cationic protein (ECP) upon ongoing immunoglobulin (Ig) production and proliferation in human B cells was studied. ECP inhibited Ig production by the human lymphoblastoid cell lines, CBL and GM-1056, in a dose-dependent fashion. In contrast, proliferation was not affected. This ECP-induced inhibition of Ig production was specific, since inhibition was blocked by anti-ECP serum but not by control serum. Interleukin (IL)-4 did not affect Ig production by CBL or GM-1056 cells; however, IL-4 reversed ECP-induced inhibition of Ig production and this reverse was blocked by anti-IL-4 antibody but not by control antibody. In contrast, other cytokines, including IL-1 beta, IL-2, IL-3, IL-5, IL-6, interferon (IFN)-alpha, and IFN-gamma, failed to reverse inhibition. ECP also inhibited spontaneous Ig production (IgM, IgG1, IgG2, IgG3, IgG4, and IgA) by tonsillar large activated B cells without affecting proliferation. This inhibition was also blocked by anti-ECP serum but not by control serum and was reversed by IL-4 specifically. These results indicate that ECP may play an important role in B cell responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0090-1229
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
84-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Inhibition of ongoing immunoglobulin production by eosinophil cationic protein.
pubmed:affiliation
Department of Pediatrics, Faculty of Medicine, Kyoto University Hospital, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't