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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-7-29
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pubmed:abstractText |
It has been suggested that germline stem cells maintain oogenesis in postnatal mouse ovaries. Here we show that adult mouse ovaries rapidly generate hundreds of oocytes, despite a small premeiotic germ cell pool. In considering the possibility of an extragonadal source of germ cells, we show expression of germline markers in bone marrow (BM). Further, BM transplantation restores oocyte production in wild-type mice sterilized by chemotherapy, as well as in ataxia telangiectasia-mutated gene-deficient mice, which are otherwise incapable of making oocytes. Donor-derived oocytes are also observed in female mice following peripheral blood transplantation. Although the fertilizability and developmental competency of the BM and peripheral blood-derived oocytes remain to be established, their morphology, enclosure within follicles, and expression of germ-cell- and oocyte-specific markers collectively support that these cells are bona fide oocytes. These results identify BM as a potential source of germ cells that could sustain oocyte production in adulthood.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:AdamsGregor BGB,
pubmed-author:BagleyJessamynJ,
pubmed-author:CortesMaria LML,
pubmed-author:ForkertRandolfR,
pubmed-author:IacominiJohnJ,
pubmed-author:JohnsonJoshuaJ,
pubmed-author:LeeHo-JoonHJ,
pubmed-author:NiikuraYuichiY,
pubmed-author:ScaddenDavid TDT,
pubmed-author:Skaznik-WikielMalgorzataM,
pubmed-author:SpitzerThomasT,
pubmed-author:TillyJacqueline CanningJC,
pubmed-author:TillyJonathan LJL,
pubmed-author:TschudyKatherine SKS
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
303-15
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:16051153-Adult,
pubmed-meshheading:16051153-Animals,
pubmed-meshheading:16051153-Biological Markers,
pubmed-meshheading:16051153-Bone Marrow,
pubmed-meshheading:16051153-Bone Marrow Cells,
pubmed-meshheading:16051153-Bone Marrow Transplantation,
pubmed-meshheading:16051153-Cell Cycle Proteins,
pubmed-meshheading:16051153-DNA-Binding Proteins,
pubmed-meshheading:16051153-Female,
pubmed-meshheading:16051153-Humans,
pubmed-meshheading:16051153-Mice,
pubmed-meshheading:16051153-Mice, Mutant Strains,
pubmed-meshheading:16051153-Mice, Transgenic,
pubmed-meshheading:16051153-Oocytes,
pubmed-meshheading:16051153-Oogenesis,
pubmed-meshheading:16051153-Ovary,
pubmed-meshheading:16051153-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:16051153-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16051153-Sterilization, Reproductive,
pubmed-meshheading:16051153-Tumor Suppressor Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood.
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pubmed:affiliation |
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Harvard Medical School, Boston, Massachusetts 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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