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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-7-29
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pubmed:abstractText |
To investigate the possible dependence on age of the rate of decline of IgG antibodies to pertussis toxin (IgG-PT) after natural infection with Bordetella pertussis we measured IgG-PT in follow-up sera of 121 patients (age 0-94 years) obtained after 123 episodes of B. pertussis infection. For analysis we applied a dynamic model for the inactivation of B. pertussis by the immune system. There were no significant differences in rise, peak and decline of IgG-PT between different age groups, although there was a tendency for a more rapid increase, a higher peak and a faster decline with increasing age. The IgG-PT cut-off of 100 U/ml for serodiagnosis of pertussis appeared valid in all age groups. A decline of IgG-PT to < 10 U/ml was associated with increased risk of re-infection with B. pertussis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0950-2688
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
737-48
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pubmed:dateRevised |
2010-5-17
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pubmed:meshHeading |
pubmed-meshheading:16050521-Adolescent,
pubmed-meshheading:16050521-Adult,
pubmed-meshheading:16050521-Age Factors,
pubmed-meshheading:16050521-Aged,
pubmed-meshheading:16050521-Aged, 80 and over,
pubmed-meshheading:16050521-Antibodies, Bacterial,
pubmed-meshheading:16050521-Bordetella pertussis,
pubmed-meshheading:16050521-Case-Control Studies,
pubmed-meshheading:16050521-Child,
pubmed-meshheading:16050521-Child, Preschool,
pubmed-meshheading:16050521-Cohort Studies,
pubmed-meshheading:16050521-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16050521-Female,
pubmed-meshheading:16050521-Follow-Up Studies,
pubmed-meshheading:16050521-Humans,
pubmed-meshheading:16050521-Immunoglobulin G,
pubmed-meshheading:16050521-Infant,
pubmed-meshheading:16050521-Male,
pubmed-meshheading:16050521-Middle Aged,
pubmed-meshheading:16050521-Netherlands,
pubmed-meshheading:16050521-Pertussis Toxin,
pubmed-meshheading:16050521-Polymerase Chain Reaction,
pubmed-meshheading:16050521-Risk Assessment,
pubmed-meshheading:16050521-Virulence Factors, Bordetella,
pubmed-meshheading:16050521-Whooping Cough
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pubmed:year |
2005
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pubmed:articleTitle |
Age-specific long-term course of IgG antibodies to pertussis toxin after symptomatic infection with Bordetella pertussis.
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pubmed:affiliation |
Department of Pediatrics, Groene Hart Hospital, Gouda, The Netherlands. florens.versteegh@ghz.nl
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pubmed:publicationType |
Journal Article
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