Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2005-7-22
pubmed:abstractText
The transplantation of neural stem cells (NSCs) offers a new potential therapeutic approach as a cell-based delivery system for gene therapy in brain tumors. This is based on the unique capacity of NSCs to migrate throughout the brain and to target invading tumor cells. However, the signals controlling the targeted migration of transplanted NSCs are poorly defined. We analyzed the in vitro and in vivo effects of angiogenic growth factors and protein extracts from surgical specimens of brain tumor patients on NSC migration. Here, we demonstrate that vascular endothelial growth factor (VEGF) is able to induce a long-range attraction of transplanted human NSCs from distant sites in the adult brain. Our results indicate that tumor-upregulated VEGF and angiogenic-activated microvasculature are relevant guidance signals for NSC tropism toward brain tumors.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-10742153, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-11070094, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-11231595, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-11969370, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-12032707, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-12086642, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-12161748, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-12167771, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-12384520, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-12778165, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-12881607, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-12943581, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-14670128, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-14691144, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-14977823, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-15153341, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-15289341, http://linkedlifedata.com/resource/pubmed/commentcorrection/16036113-9988225
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1522-8002
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
623-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16036113-Animals, pubmed-meshheading:16036113-Brain Neoplasms, pubmed-meshheading:16036113-Cell Line, Tumor, pubmed-meshheading:16036113-Cell Movement, pubmed-meshheading:16036113-Cell Transplantation, pubmed-meshheading:16036113-Cells, Cultured, pubmed-meshheading:16036113-Culture Media, Conditioned, pubmed-meshheading:16036113-Dose-Response Relationship, Drug, pubmed-meshheading:16036113-Endothelium, Vascular, pubmed-meshheading:16036113-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:16036113-Humans, pubmed-meshheading:16036113-Microscopy, Fluorescence, pubmed-meshheading:16036113-Neovascularization, Pathologic, pubmed-meshheading:16036113-Neurons, pubmed-meshheading:16036113-Polymerase Chain Reaction, pubmed-meshheading:16036113-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:16036113-Signal Transduction, pubmed-meshheading:16036113-Stem Cells, pubmed-meshheading:16036113-Swine, pubmed-meshheading:16036113-Tropism, pubmed-meshheading:16036113-Umbilical Veins, pubmed-meshheading:16036113-Up-Regulation, pubmed-meshheading:16036113-Vascular Endothelial Growth Factor A, pubmed-meshheading:16036113-Vascular Endothelial Growth Factor Receptor-1, pubmed-meshheading:16036113-Vascular Endothelial Growth Factor Receptor-2
pubmed:year
2005
pubmed:articleTitle
Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor.
pubmed:affiliation
Neurosurgical Oncology Laboratory, Department of Neurosurgery, Brigham and Women's Hospital and Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural