Source:http://linkedlifedata.com/resource/pubmed/id/16027401
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2005-7-19
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pubmed:abstractText |
ABT-578, a sirolimus analog, is being developed for administration from drug-eluting stents to prevent postimplantation neointimal hyperplasia. The purpose of this study was to evaluate the safety, tolerability, and pharmacokinetics of multiple doses of ABT-578. Healthy subjects randomly received placebo or ABT-578 (200, 400, or 800 microg) as daily intravenous infusions for 14 days. ABT-578 blood pharmacokinetics and urine excretion on days 1 and 14 were determined. The effect of ABT-578 on mitogen-stimulated lymphocyte proliferation was assessed. ABT-578 pharmacokinetics was described by a 3-compartment open model. The mean CL, V(ss), and t(1/2) ranges were 4.0 to 4.6 L/h, 92.5 to 118.0 L, and 24.7 to 31.0 hours, respectively. ABT-578 pharmacokinetics was dose and time invariant. Approximately 0.1% of ABT-578 was excreted in the urine. ABT-578 was well tolerated, and no systemic changes were observed in the mitogen-stimulated lymphocyte proliferation. ABT-578 was shown to be safe over a wide range of systemic exposures.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0091-2700
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pubmed:author |
pubmed-author:AwniWalid MWM,
pubmed-author:ChiuWenziW,
pubmed-author:EdekiTimiT,
pubmed-author:FreeneyTonyT,
pubmed-author:GrannemanRichard GRG,
pubmed-author:JiQinQ,
pubmed-author:KaryekarChetan SCS,
pubmed-author:LockeCharlesC,
pubmed-author:O'DeaRobertR,
pubmed-author:PradhanRajendra SRS,
pubmed-author:SchwartzLewis BLB
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
910-8
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pubmed:dateRevised |
2008-6-5
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pubmed:meshHeading |
pubmed-meshheading:16027401-Adult,
pubmed-meshheading:16027401-Area Under Curve,
pubmed-meshheading:16027401-Dose-Response Relationship, Drug,
pubmed-meshheading:16027401-Double-Blind Method,
pubmed-meshheading:16027401-Female,
pubmed-meshheading:16027401-Half-Life,
pubmed-meshheading:16027401-Humans,
pubmed-meshheading:16027401-Immunosuppressive Agents,
pubmed-meshheading:16027401-Male,
pubmed-meshheading:16027401-Metabolic Clearance Rate,
pubmed-meshheading:16027401-Middle Aged,
pubmed-meshheading:16027401-Sirolimus
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pubmed:year |
2005
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pubmed:articleTitle |
A phase I multiple-dose escalation study characterizing pharmacokinetics and safety of ABT-578 in healthy subjects.
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pubmed:affiliation |
Abbott Laboratories, Abbott Park Road, Abbott Park, IL 60064, USA.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Multicenter Study,
Clinical Trial, Phase I
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