Linked Life Data

16005630

Source:http://linkedlifedata.com/resource/pubmed/id/16005630

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2005-8-9
pubmed:abstractText
Bidirectional microtubule-dependent organelle transport in melanophores is regulated by cAMP through organelle-bound protein kinase A (PKA); however, the mechanisms responsible for this regulation are unknown. A recent study by Gelfand and colleagues demonstrates that, in addition to PKA, transport is regulated by the organelle-bound mitogen-activated protein kinase (MAPK) signaling components ERK and MEK, whose activity is required for bidirectional transport along microtubules. This pathway apparently acts downstream of PKA, suggesting that bidirectional organelle transport is regulated by a hierarchical cascade of signaling pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0962-8924
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
396-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Intracellular organelle transport: few motors, many signals.
pubmed:affiliation
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, 143 Rosenthal, Philadelphia, PA 19104, USA.
pubmed:publicationType
Journal Article