Linked Life Data

16003820

Source:http://linkedlifedata.com/resource/pubmed/id/16003820

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2005-9-6
pubmed:abstractText
The association of various alpha-amino acids with four new, coordinatively unsaturated metal complexes ([Cu(5)]2+, [Cu(6)]2+, [Cu(7)]2+, and [Zn(8)]2+) was examined. The receptors [Cu(5)]2+ and [Cu(7)]2+ were found to discriminate histidine (His) from other zwitterionic alpha-amino acids by means of indicator-displacement assays (IDAs) using 5(6)-carboxyfluorescein as an indicator in buffered methanol/water (3:1) solvent. The colorimetric detection of His was achieved by using this IDA method, which appears to owe its selectivity to a unique process involving disruption of the host complex to form a 2:1 His/Cu(II) complex rather than simple indicator displacement. The occurrence of distinct intermolecular coordination processes in response to the introduction of a different amino acid is observed. X-ray crystal structures of the host metal complexes were obtained and exhibit the adoption of a variety of coordination geometries about the metal center.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0947-6539
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5319-26
pubmed:dateRevised
2009-8-4
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
"Naked-eye" detection of histidine by regulation of Cu(II) coordination modes.
pubmed:affiliation
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78701, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural