Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-7-29
pubmed:abstractText
Rac3 may play an important role in tumor growth but little is known about its expression and mutation in human tumor tissues. We examined the expression of Rac3 using RT-PCR and mutation of the Rac3 gene by DNA sequencing. Overexpression of the Rac3 gene occurred in 19% (5/26) of brain tumors; 3 of 9 (33%) meningiomas, 1 of 11 (9%) astrocytomas and 1 of 6 (17%) pituitary adenomas. Two of the 3 meningiomas with Rac3 overexpression were recurrent meningiomas. The only astrocytoma with Rac3 overexpression was a glioblastoma multiforme. Mutation of the Rac3 gene occurred in 63% (12/19) of brain tumours; 4 of 7 (57.1%) meningiomas, 4 of 5 (80%) pituitary adenomas and 4 of 7 (57.1%) astrocytomas. Except in one astrocytoma, the other four tumors with Rac3 overexpression (3 meningiomas and one pituitary adenoma) did not have Rac3 mutations. Our data is the first report of the frequency of Rac3 overexpression and mutation in human brain tumors. Overexpression may be associated with aggressive tumor behavior. The relationship between Rac3 expression and mutation requires further investigation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0967-5868
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
571-4
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15993075-Astrocytoma, pubmed-meshheading:15993075-Brain Neoplasms, pubmed-meshheading:15993075-Cell Transformation, Neoplastic, pubmed-meshheading:15993075-Chromosomes, Human, Pair 17, pubmed-meshheading:15993075-DNA Mutational Analysis, pubmed-meshheading:15993075-GTP Phosphohydrolases, pubmed-meshheading:15993075-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15993075-Genetic Testing, pubmed-meshheading:15993075-Humans, pubmed-meshheading:15993075-Meningioma, pubmed-meshheading:15993075-Mutation, pubmed-meshheading:15993075-Neoplasm Invasiveness, pubmed-meshheading:15993075-Pituitary Neoplasms, pubmed-meshheading:15993075-Predictive Value of Tests, pubmed-meshheading:15993075-RNA, Messenger, pubmed-meshheading:15993075-Signal Transduction, pubmed-meshheading:15993075-Tumor Markers, Biological, pubmed-meshheading:15993075-rac GTP-Binding Proteins
pubmed:year
2005
pubmed:articleTitle
Expression of Rac3 in human brain tumors.
pubmed:affiliation
Division of Neurosurgery, Kaohsiung Medical Universiy, Kaohsiung, Taiwan.
pubmed:publicationType
Journal Article, Comparative Study