Linked Life Data

15991223

Source:http://linkedlifedata.com/resource/pubmed/id/15991223

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-7-6
pubmed:abstractText
A semi-quantitative expression analysis of both AML1-a and AML1-total was performed by RT-PCR in 19 children with acute lymphoblastic leukemia (ALL) at diagnosis. AML1-a expression was assessed in 16 bone marrow (BM) and 13 peripheral blood (PB) samples whereas AML1-total was assessed in 17 BM and 16 PB samples. These analyses were also carried out in 15 PB samples of healthy controls. In addition, 18/19 patients were karyotyped: 11 had an unmodified constitutional karyotype (CK) and seven exhibited acquired chromosomal abnormalities (ACA). The expression of AML1-a was significantly increased in BM and PB when compared with the controls (p < 0.013 and p < 0.035, respectively). A significant increase was found in the expression of AML1-a in BM of the ACA group compared with the CK group (p < 0.0009). The expression of AML1-a in BM and PB showed a significant increase in the ACA group compared with controls (p < 0.00001 and p < 0.012, respectively); in contrast, the CK group did not differ from the controls. These observations may mean that the increase of AML1-a favours the progression of leukemia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0278-0232
pubmed:author
pubmed:copyrightInfo
Copyright 2005 John Wiley & Sons, Ltd
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-90
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15991223-Adolescent, pubmed-meshheading:15991223-Bone Marrow, pubmed-meshheading:15991223-Child, pubmed-meshheading:15991223-Child, Preschool, pubmed-meshheading:15991223-Chromosome Aberrations, pubmed-meshheading:15991223-Chromosomes, Human, Pair 21, pubmed-meshheading:15991223-Core Binding Factor Alpha 2 Subunit, pubmed-meshheading:15991223-DNA-Binding Proteins, pubmed-meshheading:15991223-Female, pubmed-meshheading:15991223-Gene Expression Regulation, Leukemic, pubmed-meshheading:15991223-Humans, pubmed-meshheading:15991223-Karyotyping, pubmed-meshheading:15991223-Male, pubmed-meshheading:15991223-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:15991223-Proto-Oncogene Proteins, pubmed-meshheading:15991223-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:15991223-Transcription Factors
pubmed:year
2004
pubmed:articleTitle
Increased expression of AML1-a and acquired chromosomal abnormalities in childhood acute lymphoblastic leukemia.
pubmed:affiliation
División de Genética, Centro de Investigación Biomédica de Occidente, IMSS, Tepatitlán, Jalisco, México.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't