Linked Life Data

15970507

Source:http://linkedlifedata.com/resource/pubmed/id/15970507

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-6-22
pubmed:abstractText
The gene knockout technology has revolutionized the fertility/infertility field. It has revealed several essential previously undiscovered molecules, new insights and novel mechanisms involved in steps of the fertility cascade in females. Using database and literature search, knockouts of at least 83 genes were discovered that demonstrated an effect on fertility of female mice. These effects ranged from abnormality in reproductive structure, ovarian function, oocyte, fertilization, embryonic and fetal development, implantation and pregnancy to delivery. However, only a few of these knockout of genes such as encoding oocyte glycoprotein coat comprised of zona pellucida (ZP) 1, ZP2 and ZP3 and oocute plasma membrane specific proteins showed a specific and exclusive target infertility effect without concomitant effects on the non-reproductive organ system. These molecules will provide novel targets of contraception including contraceptive vaccine development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2447-59
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Gene knockouts that cause female infertility: search for novel contraceptive targets.
pubmed:affiliation
Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Health Science Center, Morgantown, WV 26506-9186, USA. rnaz@hsc.wvu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, N.I.H., Extramural