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rdf:type |
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lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0009170,
umls-concept:C0016733,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035696,
umls-concept:C0066908,
umls-concept:C0205191,
umls-concept:C0205253,
umls-concept:C0441889,
umls-concept:C0442805,
umls-concept:C2825032
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-6-13
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pubmed:abstractText |
An increase in preprodynorphin (ppdyn) mRNA was detected in the caudate putamen of chronically cocaine-treated and 3-h withdrawn rats. An increase in mu-opioid receptor (MOP) mRNA levels was observed in the frontal cortex of 3-h withdrawn rats. Naloxone had no effect on the increase of MOP or ppdyn mRNA levels. The results indicate that the opioid system is altered during early withdrawal from chronic cocaine administration.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/preproenkephalin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0169-328X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
258-62
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15950784-Animals,
pubmed-meshheading:15950784-Brain Chemistry,
pubmed-meshheading:15950784-Cocaine,
pubmed-meshheading:15950784-Cocaine-Related Disorders,
pubmed-meshheading:15950784-Disease Models, Animal,
pubmed-meshheading:15950784-Dopamine Uptake Inhibitors,
pubmed-meshheading:15950784-Down-Regulation,
pubmed-meshheading:15950784-Drug Administration Schedule,
pubmed-meshheading:15950784-Enkephalins,
pubmed-meshheading:15950784-Frontal Lobe,
pubmed-meshheading:15950784-Male,
pubmed-meshheading:15950784-Narcotic Antagonists,
pubmed-meshheading:15950784-Protein Precursors,
pubmed-meshheading:15950784-RNA, Messenger,
pubmed-meshheading:15950784-Rats,
pubmed-meshheading:15950784-Rats, Inbred F344,
pubmed-meshheading:15950784-Receptors, Opioid, mu,
pubmed-meshheading:15950784-Substance Withdrawal Syndrome,
pubmed-meshheading:15950784-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex.
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pubmed:affiliation |
Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA. baileya@rockefeller.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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