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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-6-10
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pubmed:abstractText |
Evidence shows that leukotriene receptor antagonist (LTRA) can cause a partial reduction of eosinophils in the asthmatic airway. Although cysteinyl leukotrienes (CysLTs) can regulate the development of eosinophilic inflammation, LTRA might modulate the eosinophilic response to other inflammatory molecules involved in allergic inflammation. Montelukast is an LTRA that inhibits eosinophil transendothelial migration (TEM) in response to platelet-activating factor (PAF). The present study evaluates whether pranlukast (an LTRA) modifies eosinophil TEM in response to chemoattractants including PAF and C-C chemokines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCL11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL11,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL5,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene D4,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Activating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leukotriene,
http://linkedlifedata.com/resource/pubmed/chemical/leukotriene D4 receptor,
http://linkedlifedata.com/resource/pubmed/chemical/pranlukast
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pubmed:status |
MEDLINE
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pubmed:issn |
1018-2438
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2005 S. Karger AG, Basel.
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pubmed:issnType |
Print
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pubmed:volume |
137 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15947477-Adult,
pubmed-meshheading:15947477-Cell Movement,
pubmed-meshheading:15947477-Chemokine CCL11,
pubmed-meshheading:15947477-Chemokine CCL5,
pubmed-meshheading:15947477-Chemokines, CC,
pubmed-meshheading:15947477-Chromones,
pubmed-meshheading:15947477-Drug Interactions,
pubmed-meshheading:15947477-Endothelial Cells,
pubmed-meshheading:15947477-Eosinophils,
pubmed-meshheading:15947477-Female,
pubmed-meshheading:15947477-Humans,
pubmed-meshheading:15947477-Leukotriene Antagonists,
pubmed-meshheading:15947477-Leukotriene D4,
pubmed-meshheading:15947477-Male,
pubmed-meshheading:15947477-Membrane Proteins,
pubmed-meshheading:15947477-Platelet Activating Factor,
pubmed-meshheading:15947477-Receptors, Leukotriene
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pubmed:year |
2005
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pubmed:articleTitle |
Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils.
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pubmed:affiliation |
Department of Respiratory Medicine, Saitama Medical School, Japan. favre4mn@saitama-med.ac.jp
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pubmed:publicationType |
Journal Article
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