| pubmed-article:15932314 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15932314 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:15932314 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:15932314 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:15932314 | lifeskim:mentions | umls-concept:C0074995 | lld:lifeskim |
| pubmed-article:15932314 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15932314 | pubmed:dateCreated | 2005-6-3 | lld:pubmed |
| pubmed-article:15932314 | pubmed:abstractText | The receptor for the lipid mediator sphingosylphosphorylcholine (SPC) has not yet been identified. We describe here the synthesis of the first photoaffinity analogue of SPC. This probe, which contains a 14C-isotopic label in the choline methyl groups and a photoreactive benzophenone in the long-chain base, may be a useful tool in the identification of the G protein coupled receptors that have been postulated to interact directly and specifically with SPC and in the definition of the ligand-binding sites. The key steps in the synthesis are selective reduction of the triple bond in enyne 6 to install the 4E double bond, Suzuki coupling to incorporate the benzophenone photophore at the end of the sphingoid chain, and reduction of the 2-azidoethyl phosphate headgroup of 13 followed by N,N,N-trimethylation to introduce the radiolabel into the choline moiety. The synthesis was completed by the release of the amino group at C2 of the sphingoid base of SPC analogue 2. | lld:pubmed |
| pubmed-article:15932314 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15932314 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15932314 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15932314 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15932314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15932314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15932314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15932314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15932314 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15932314 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15932314 | pubmed:issn | 0022-3263 | lld:pubmed |
| pubmed-article:15932314 | pubmed:author | pubmed-author:BittmanRobert... | lld:pubmed |
| pubmed-article:15932314 | pubmed:author | pubmed-author:LuXuequanX | lld:pubmed |
| pubmed-article:15932314 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15932314 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:15932314 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:15932314 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15932314 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15932314 | pubmed:pagination | 4746-50 | lld:pubmed |
| pubmed-article:15932314 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15932314 | pubmed:meshHeading | pubmed-meshheading:15932314... | lld:pubmed |
| pubmed-article:15932314 | pubmed:meshHeading | pubmed-meshheading:15932314... | lld:pubmed |
| pubmed-article:15932314 | pubmed:meshHeading | pubmed-meshheading:15932314... | lld:pubmed |
| pubmed-article:15932314 | pubmed:meshHeading | pubmed-meshheading:15932314... | lld:pubmed |
| pubmed-article:15932314 | pubmed:meshHeading | pubmed-meshheading:15932314... | lld:pubmed |
| pubmed-article:15932314 | pubmed:meshHeading | pubmed-meshheading:15932314... | lld:pubmed |
| pubmed-article:15932314 | pubmed:meshHeading | pubmed-meshheading:15932314... | lld:pubmed |
| pubmed-article:15932314 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15932314 | pubmed:articleTitle | Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue. | lld:pubmed |
| pubmed-article:15932314 | pubmed:affiliation | Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, New York 11367-1597, USA. | lld:pubmed |
| pubmed-article:15932314 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15932314 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15932314 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15932314 | lld:pubmed |
