| pubmed-article:15931062 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15931062 | lifeskim:mentions | umls-concept:C0206745 | lld:lifeskim |
| pubmed-article:15931062 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:15931062 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:15931062 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15931062 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15931062 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15931062 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15931062 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15931062 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:15931062 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15931062 | pubmed:dateCreated | 2005-6-2 | lld:pubmed |
| pubmed-article:15931062 | pubmed:abstractText | The serotonin-1A [5-hydroxytryptamine 1A (5HT1A)] receptor is important for emotional and homeostatic processes in the central nervous system. In the hippocampus, the 5HT1A receptor couples to inhibitory Gi/o proteins to decrease pyramidal cell excitability. Here we investigate the 5HT1A receptor in a mouse deficient in the alpha-subunit of Gz protein (Galphaz knock-out). Behavioural tests showed heightened anxiety and depression-like behaviour in the Galphaz knock-out mice. Whole-cell recording in CA1 pyramidal neurons showed a significantly greater 5HT1A receptor-mediated potassium current in Galphaz knock-out mice. The effect was independent of 5HT4 receptors as the slow after-hyperpolarization was unaffected and a slow depolarization was absent in the Galphaz knock-out mice. Other receptors linked to Gi/o proteins [gamma-aminobutyric acid type B receptor (GABAB), adenosine A1 and muscarinic acetylcholine receptors] were not affected in Galphaz knock-out mice. These results suggest that the 5HT1A receptor may be linked to Galphaz protein, as reported previously in cell culture but shown here in an intact neural network. | lld:pubmed |
| pubmed-article:15931062 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15931062 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15931062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15931062 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15931062 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15931062 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:15931062 | pubmed:author | pubmed-author:HendryIan AIA | lld:pubmed |
| pubmed-article:15931062 | pubmed:author | pubmed-author:OleskevichSha... | lld:pubmed |
| pubmed-article:15931062 | pubmed:author | pubmed-author:LeckKwong-Joo... | lld:pubmed |
| pubmed-article:15931062 | pubmed:author | pubmed-author:MatthaeiKlaus... | lld:pubmed |
| pubmed-article:15931062 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15931062 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:15931062 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:15931062 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15931062 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15931062 | pubmed:pagination | 921-5 | lld:pubmed |
| pubmed-article:15931062 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15931062 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15931062 | pubmed:articleTitle | Enhanced serotonin response in the hippocampus of Galphaz protein knock-out mice. | lld:pubmed |
| pubmed-article:15931062 | pubmed:affiliation | Garvan Institute of Medical Research, Sydney, Australia. S.Oleskevich@garvan.org.au | lld:pubmed |
| pubmed-article:15931062 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15931062 | pubmed:publicationType | Comparative Study | lld:pubmed |
| entrez-gene:14687 | entrezgene:pubmed | pubmed-article:15931062 | lld:entrezgene |
| entrez-gene:66665 | entrezgene:pubmed | pubmed-article:15931062 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15931062 | lld:pubmed |
