|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2005-6-2
|
|
pubmed:abstractText |
The serotonin-1A [5-hydroxytryptamine 1A (5HT1A)] receptor is important for emotional and homeostatic processes in the central nervous system. In the hippocampus, the 5HT1A receptor couples to inhibitory Gi/o proteins to decrease pyramidal cell excitability. Here we investigate the 5HT1A receptor in a mouse deficient in the alpha-subunit of Gz protein (Galphaz knock-out). Behavioural tests showed heightened anxiety and depression-like behaviour in the Galphaz knock-out mice. Whole-cell recording in CA1 pyramidal neurons showed a significantly greater 5HT1A receptor-mediated potassium current in Galphaz knock-out mice. The effect was independent of 5HT4 receptors as the slow after-hyperpolarization was unaffected and a slow depolarization was absent in the Galphaz knock-out mice. Other receptors linked to Gi/o proteins [gamma-aminobutyric acid type B receptor (GABAB), adenosine A1 and muscarinic acetylcholine receptors] were not affected in Galphaz knock-out mice. These results suggest that the 5HT1A receptor may be linked to Galphaz protein, as reported previously in cell culture but shown here in an intact neural network.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Baclofen,
http://linkedlifedata.com/resource/pubmed/chemical/Carbachol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholinergic Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/Gnaz protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1A,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/WAY 100635
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0959-4965
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
21
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
921-5
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15931062-Adenosine,
pubmed-meshheading:15931062-Animals,
pubmed-meshheading:15931062-Baclofen,
pubmed-meshheading:15931062-Behavior, Animal,
pubmed-meshheading:15931062-Blotting, Western,
pubmed-meshheading:15931062-Carbachol,
pubmed-meshheading:15931062-Cholinergic Agonists,
pubmed-meshheading:15931062-Drug Interactions,
pubmed-meshheading:15931062-Electric Conductivity,
pubmed-meshheading:15931062-Electric Stimulation,
pubmed-meshheading:15931062-Fluorescent Antibody Technique,
pubmed-meshheading:15931062-GABA Agonists,
pubmed-meshheading:15931062-GTP-Binding Protein alpha Subunits,
pubmed-meshheading:15931062-Hippocampus,
pubmed-meshheading:15931062-Membrane Potentials,
pubmed-meshheading:15931062-Mice,
pubmed-meshheading:15931062-Mice, Inbred C57BL,
pubmed-meshheading:15931062-Mice, Knockout,
pubmed-meshheading:15931062-Patch-Clamp Techniques,
pubmed-meshheading:15931062-Piperazines,
pubmed-meshheading:15931062-Potassium,
pubmed-meshheading:15931062-Pyramidal Cells,
pubmed-meshheading:15931062-Pyridines,
pubmed-meshheading:15931062-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:15931062-Serotonin,
pubmed-meshheading:15931062-Serotonin Antagonists,
pubmed-meshheading:15931062-Swimming
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Enhanced serotonin response in the hippocampus of Galphaz protein knock-out mice.
|
|
pubmed:affiliation |
Garvan Institute of Medical Research, Sydney, Australia. S.Oleskevich@garvan.org.au
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
