Linked Life Data

15929707

Source:http://linkedlifedata.com/resource/pubmed/id/15929707

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-6-2
pubmed:databankReference
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444799, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444800, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444801, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444803, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444804, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444805, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444806, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444807, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444808, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444809, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444810, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444811, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY444812
pubmed:abstractText
Infections with non-B HIV-1 subtypes are rare in the United States, but comprise a significant percentage of infections among U.S. military personnel. Risk behavior while on overseas deployment correlates with non-B infection in this population. Extensive genetic characterization will be required to define HIV-1 diversity, and to effectively evaluate requirements for HIV-1 vaccines and other prevention strategies in this group. From 1997 to 2000, 520 recent seroconverters, identified through routine HIV-1 testing in the U.S. active military force, volunteered for a prospective study. V3 loop serology or partial genome sequencing identified 28 non- B subtype infections; 14 were studied by full genome sequencing and phylogenetic analysis. Five strains were CRF01_AE. Four of these clustered with CM240 from Thailand, and one clustered with African CRF01_AE. Four strains were CRF02_AG, prevalent in West and West Central Africa. Two strains were subtype C. One strain was a unique recombinant between CRF01_AE and subtype B, and another was a complex unique recombinant between subtype A and D. The final strain was a member of a complex circulating recombinant first identified in Senegal, CRF09_cpx, incorporating subtypes A, F, G, and an unclassified genome. This diversity of non-B subtype HIV-1 strains, encompassing three globally prevalent non-B strains and including rare or even possibly unique strains, illustrates the breadth of U.S. military exposure while deployed and sets the bar higher for breadth of cross-subtype protection to be afforded by an HIV-1 vaccine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0889-2229
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
424-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Characterization of complete HIV type 1 genomes from non-B subtype infections in U.S. military personnel.
pubmed:affiliation
US Military HIV Research Program, Henry M. Jackson Foundation, Rockville, Maryland 20850, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural