Source:http://linkedlifedata.com/resource/pubmed/id/15903968
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2005-5-20
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pubmed:abstractText |
Cells in multicellular organisms switch between distinct cell fates, such as proliferation or differentiation into specialized cell types. Genome-wide gene regulatory networks govern this behavior. Theoretical studies of complex networks suggest that they can exhibit ordered (stable) dynamics, raising the possibility that cell fates may represent high-dimensional attractor states. We used gene expression profiling to show that trajectories of neutrophil differentiation converge to a common state from different directions of a 2773-dimensional gene expression state space, providing the first experimental evidence for a high-dimensional stable attractor that represents a distinct cellular phenotype.
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pubmed:keyword | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0031-9007
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
128701
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15903968-Cell Differentiation,
pubmed-meshheading:15903968-Dimethyl Sulfoxide,
pubmed-meshheading:15903968-Gene Expression Profiling,
pubmed-meshheading:15903968-Gene Expression Regulation,
pubmed-meshheading:15903968-HL-60 Cells,
pubmed-meshheading:15903968-Humans,
pubmed-meshheading:15903968-Neutrophils,
pubmed-meshheading:15903968-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:15903968-RNA, Messenger,
pubmed-meshheading:15903968-Tretinoin
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pubmed:year |
2005
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pubmed:articleTitle |
Cell fates as high-dimensional attractor states of a complex gene regulatory network.
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pubmed:affiliation |
Vascular Biology Program, Departments of Pathology & Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. sui.huang@childrens.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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