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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1992-6-25
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pubmed:abstractText |
A neural origin of Ewing's sarcoma (ES) has often been suggested and we have demonstrated neurofilament protein expression in ES cells. However, only the 200-kD subunit has been revealed in all of the ES cells analyzed. The 160- and 68-kD subunits were always absent. For these reasons, we have attempted to induce neural differentiation in 3 ES cell lines with different types of inducers: tetradecanoylphorbol-13-acetate (TPA) retinoic acid and nerve growth factor. When the cell lines were cultured for 7 days with TPA (10(-9) M) or retinoic acid (10(-7) M), only the 68-kD neurofilament subunit was slightly induced. No inducation was obtained when nerve growth factor was used, even at a 21-day culture. These results are in agreement with the putative neural origin of ES and may indicate an abnormal expression of neurofilament proteins in this tumor.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1010-4283
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
36-43
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1589695-Cell Division,
pubmed-meshheading:1589695-Cell Line,
pubmed-meshheading:1589695-Flow Cytometry,
pubmed-meshheading:1589695-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:1589695-Humans,
pubmed-meshheading:1589695-Microscopy, Electron,
pubmed-meshheading:1589695-Neurofilament Proteins,
pubmed-meshheading:1589695-Sarcoma, Ewing,
pubmed-meshheading:1589695-Tetradecanoylphorbol Acetate,
pubmed-meshheading:1589695-Tretinoin,
pubmed-meshheading:1589695-Tumor Cells, Cultured
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pubmed:year |
1992
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pubmed:articleTitle |
Abnormal expression of neurofilament proteins in Ewing's sarcoma cell cultures.
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pubmed:affiliation |
Centre Georges-François-Leclerc, Dijon, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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