GENERIC 15895554

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0035668, umls-concept:C0087012, umls-concept:C0699748
pubmed:issue	1
pubmed:dateCreated	2005-5-17
pubmed:abstractText	The underlying cause of a number of autosomal dominant spinocerebellar ataxias is the expansion of various types of simple sequence repeats located in diverse functional regions of different single genes. The genetic heterogeneity of these diseases which contrasts with the similarity of their pathology sites and clinical symptoms justifies the search for the shared mechanism of pathogenesis. In this article we discuss the arguments which are in favor of the RNA-mediated pathomechanism.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101089443
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/RNA
pubmed:status	MEDLINE
pubmed:issn	1473-4222
pubmed:author	pubmed-author:KrzyzosiakWlodzimierz JWJ, pubmed-author:MichlewskiGracjanG
pubmed:issnType	Print
pubmed:volume	4
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	19-24
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:15895554-Heterozygote, pubmed-meshheading:15895554-Humans, pubmed-meshheading:15895554-Models, Molecular, pubmed-meshheading:15895554-Models, Neurological, pubmed-meshheading:15895554-RNA, pubmed-meshheading:15895554-Spinocerebellar Ataxias, pubmed-meshheading:15895554-Trinucleotide Repeat Expansion
pubmed:year	2005
pubmed:articleTitle	Pathogenesis of spinocerebellar ataxias viewed from the RNA perspective.
pubmed:affiliation	Laboratory of Cancer Genetics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't