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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-5-17
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pubmed:abstractText |
A new microbial metabolite Sch 725424 (1) was isolated from the culture of Kitasatospora sp. The structure elucidation of 1 was accomplished based on NMR spectroscopic analyses as well as extensive structure elucidation of its dehydration product Sch 725428 (2). Compound 1 showed inhibitory activity against Staphylococcus aureus with MIC values 1-2 microg/ml, and also displayed weak antifungal activity against Saccharomyces cerevisiae (PM503) with an MIC 32 microg/ml.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
192-5
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pubmed:meshHeading |
pubmed-meshheading:15895527-Amides,
pubmed-meshheading:15895527-Anti-Bacterial Agents,
pubmed-meshheading:15895527-Antifungal Agents,
pubmed-meshheading:15895527-Fermentation,
pubmed-meshheading:15895527-Furans,
pubmed-meshheading:15895527-Magnetic Resonance Spectroscopy,
pubmed-meshheading:15895527-Microbial Sensitivity Tests,
pubmed-meshheading:15895527-Molecular Structure,
pubmed-meshheading:15895527-Polyenes,
pubmed-meshheading:15895527-Saccharomyces cerevisiae,
pubmed-meshheading:15895527-Staphylococcus aureus,
pubmed-meshheading:15895527-Streptomycetaceae
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pubmed:year |
2005
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pubmed:articleTitle |
New antibiotic Sch 725424 and its dehydration product Sch 725428 from Kitasatospora sp.
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pubmed:affiliation |
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. shu-wei.yang@spcorp.com
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pubmed:publicationType |
Journal Article
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