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pubmed-article:15894981pubmed:abstractTextThe CHARM program was designed as 3 separate randomized trials comparing candesartan with placebo in patients with chronic heart failure (CHF) who (1) were intolerant to angiotensin-converting enzyme inhibitor and had left ventricular ejection fraction (LVEF) < or =0.40; (2) were on angiotensin-converting enzyme inhibitor and had LVEF < or =0.40; or (3) had LVEF >0.40. CHARM provides an interesting example of the challenges faced by a Data and Safety Monitoring Committee (DSMC).lld:pubmed
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pubmed-article:15894981pubmed:articleTitleThe data monitoring experience in the Candesartan in Heart Failure Assessment of Reduction in Mortality and morbidity (CHARM) program.lld:pubmed
pubmed-article:15894981pubmed:affiliationMedical Statistics Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom.lld:pubmed
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