| pubmed-article:15886114 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15886114 | lifeskim:mentions | umls-concept:C0206431 | lld:lifeskim |
| pubmed-article:15886114 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
| pubmed-article:15886114 | lifeskim:mentions | umls-concept:C0221284 | lld:lifeskim |
| pubmed-article:15886114 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15886114 | pubmed:dateCreated | 2005-5-11 | lld:pubmed |
| pubmed-article:15886114 | pubmed:abstractText | Adhesion molecules are known to mediate cell-cell interactions, particularly those between T cells and antigen-presenting or target cells. Recent studies identified ICAM-1 as a co-stimulatory ligand that binds to lymphocyte function associated antigen-1 (LFA-1), thereby promoting the activation of T cells. As ICAM-1 is expressed on virtually any cell, it becomes a crucial molecule for the activation of CD8(+) T cells in the absence of co-stimulation provided by CD80 and CD86 molecules. In addition, ICAM-1 might function as cell-surface receptor, capable of initiating intracellular signaling. ICAM-1 is associated with other cell molecules, including MHC-I proteins, and our recent data show that productive engagement of ICAM-1 on target cells leads to recruitment of the MHC-I proteins to the contact area and enhances presentation of cognate peptide MHC-I complexes to cytotoxic T cells. | lld:pubmed |
| pubmed-article:15886114 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15886114 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15886114 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15886114 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15886114 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15886114 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15886114 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15886114 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15886114 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15886114 | pubmed:issn | 0952-7915 | lld:pubmed |
| pubmed-article:15886114 | pubmed:author | pubmed-author:DustinMichael... | lld:pubmed |
| pubmed-article:15886114 | pubmed:author | pubmed-author:LebedevaTatia... | lld:pubmed |
| pubmed-article:15886114 | pubmed:author | pubmed-author:SykulevYuriY | lld:pubmed |
| pubmed-article:15886114 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15886114 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:15886114 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15886114 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15886114 | pubmed:pagination | 251-8 | lld:pubmed |
| pubmed-article:15886114 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15886114 | pubmed:meshHeading | pubmed-meshheading:15886114... | lld:pubmed |
| pubmed-article:15886114 | pubmed:meshHeading | pubmed-meshheading:15886114... | lld:pubmed |
| pubmed-article:15886114 | pubmed:meshHeading | pubmed-meshheading:15886114... | lld:pubmed |
| pubmed-article:15886114 | pubmed:meshHeading | pubmed-meshheading:15886114... | lld:pubmed |
| pubmed-article:15886114 | pubmed:meshHeading | pubmed-meshheading:15886114... | lld:pubmed |
| pubmed-article:15886114 | pubmed:meshHeading | pubmed-meshheading:15886114... | lld:pubmed |
| pubmed-article:15886114 | pubmed:meshHeading | pubmed-meshheading:15886114... | lld:pubmed |
| pubmed-article:15886114 | pubmed:meshHeading | pubmed-meshheading:15886114... | lld:pubmed |
| pubmed-article:15886114 | pubmed:meshHeading | pubmed-meshheading:15886114... | lld:pubmed |
| pubmed-article:15886114 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15886114 | pubmed:articleTitle | ICAM-1 co-stimulates target cells to facilitate antigen presentation. | lld:pubmed |
| pubmed-article:15886114 | pubmed:affiliation | Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. | lld:pubmed |
| pubmed-article:15886114 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15886114 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15886114 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:15886114 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:3383 | entrezgene:pubmed | pubmed-article:15886114 | lld:entrezgene |
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