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pubmed-article:15872254pubmed:abstractTextThe genetic and antigenic variability of human respiratory syncytial virus (HRSV) strains isolated in Buenos Aires from 1995 to 2001 was evaluated by partial nucleotide sequencing of the G gene and enzyme-linked immunosorbent assay analysis with anti-G monoclonal antibodies. Phylogenetic analyses showed that 37 group A strains clustered into five genotypes, whereas 20 group B strains clustered into three genotypes. Group A showed more genetic variability than group B. A close correlation between genotypes and antigenic patterns was observed. Changes detected in the G protein of viruses from both groups included (i) amino acid substitutions and(ii) differences in protein length due to either changes in stop codon usage or sequence duplications. Three B strains from 1999 exhibited a duplication of 20 amino acids, while one B strain from 2001 had 2 amino acids duplicated. The comparison among Argentinean HRSV strains and viruses isolated in other geographical areas during different epidemics is discussed.lld:pubmed
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pubmed-article:15872254pubmed:authorpubmed-author:MeleroJosé...lld:pubmed
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pubmed-article:15872254pubmed:articleTitleGenetic and antigenic variability of human respiratory syncytial virus (groups a and b) isolated over seven consecutive seasons in Argentina (1995 to 2001).lld:pubmed
pubmed-article:15872254pubmed:affiliationLaboratorio de Virología Clínica, Centro de Educacion Médica e Investigaciones Clínicas, CEMIC, Hospiatal Universitario, Buenos Aires, Argentina.lld:pubmed
pubmed-article:15872254pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15872254pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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