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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1979-12-20
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pubmed:abstractText |
Mice were infected intravenously with increasing numbers of Mycobacterium habana (simiae serotype II), and the levels of delayed-type hypersensitivity to purified protein derivative and M. habana cytoplasmic protein antigen were determined after 14, 30, and 90 days. A footpad delayed-type hypersensitivity response was seen in 14-day-infected mice and was followed by a persisting anergy. T-cell-enriched suspensions collected 30 and 90 days into the infection (anergic donors) showed depressed transformation indexes after phytohemagglutinin and M. habana cytoplasmic protein antigen treatment in vitro. The corresponding B-cell mitogen (lipopolysaccharide) responses were not affected. Mixing experiments with T-cell-enriched suspensions from day-90 M. habana-infected donors adoptively suppressed lymphocyte transformation by normal and day-14 spleen cells. This effect could be ablated by anti-theta serum and complement treatment of the day-90 cells, indicating that the lack of in vitro responsiveness to cytoplasmic protein antigen was mediated by a population of suppressor T-cells present in the heavily infected spleens. There was no evidence that similar cells were present in the spleens of the 14-day-infected animals. Suppressor T-cells could be induced in vitro by exposure of day-14 spleen cells to concanavalin A or M. habana cytoplasmic protein antigen before they were mixed with normal or day-14 indicator splenic lymphocytes. The timing of the appearance of suppressor T-cells in the infected spleens corresponded to a loss of footpad hypersensitivity by the M. habana-infected animals.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-1006166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-1123253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-1167440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-123519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-13901292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-149769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-305890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-342604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-383613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-4198199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-4248603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-4278310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-4590279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-4604462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-4641854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-46586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-4869698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-4945738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-5002229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-5266318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-5456418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/158568-766585
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
497-506
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:158568-Animals,
pubmed-meshheading:158568-Antigens, Bacterial,
pubmed-meshheading:158568-Disease Models, Animal,
pubmed-meshheading:158568-Hypersensitivity, Delayed,
pubmed-meshheading:158568-Immunity, Cellular,
pubmed-meshheading:158568-Leprosy,
pubmed-meshheading:158568-Lymphocyte Activation,
pubmed-meshheading:158568-Mice,
pubmed-meshheading:158568-Mice, Inbred Strains,
pubmed-meshheading:158568-Mycobacterium,
pubmed-meshheading:158568-Mycobacterium Infections,
pubmed-meshheading:158568-Spleen,
pubmed-meshheading:158568-T-Lymphocytes, Regulatory
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pubmed:year |
1979
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pubmed:articleTitle |
Development of suppressor T-cells in Mycobacterium habana-infected mice.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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